C8: The Impact of Physical and Chemical Parameters on the Exposure of Hazardous Drugs in the Workplace

Kansas City Convention Center 

Room: 3501 H 

CM Credit Hours: 1 

Physical and chemical properties of chemicals impact the potential for inhalation and dermal exposure. Key properties will be evaluated as they relate to hazardous drug (HD) exposure. The potential for exposures to vapors from HDs has been a common misconception in the healthcare industry. This presentation will provide evidence that the vapor pressure of the NIOSH listed HDs is generally minimal and will be applied to an exaggerated exposure case study example with cyclophosphamide demonstrating extremely low exposure potential from HD vapors. This indicates that dust and aerosol evaluation is the appropriate sampling approach for potential inhalation exposure. Dermal route of exposure is of concern in the healthcare setting. The second evaluation presented here will investigate how the potential for dermal absorption of HDs contributes to a possible internal dose. Physical and chemical parameters (i.e., molecular weight, octanol-water partition coefficient, and water solubility) were used with in silico models to predict dermal absorption potential. These results can then feed into the toxicological assessment and determination of an acceptable surface limit (ASL).

After listening to this presentation, the attendee should be able to:

Demonstrate that vapor pressure is relatively low indicating very low HD exposure by inhalation and aerosol evaluation techniques are most appropriate.

Strengthen knowledge about in silico models to estimate dermal absorption for HDs to support acceptable surface limit determination. 

Intermediate

Q&A

Corporation/Company

Healthcare/Pharma

Laboratories

Manufacturing

Available as part of AIHA Connect OnDemand

Hazard Recognition/Exposure Assessment

Health Care

Toxicology