Wednesday, Jul 26: 9:30 AM - 10:15 AM
Aging and neurodegeneration are associated with changes in brain tissue at the molecular level, affecting its organization, density, and composition. These changes can be detected using quantitative MRI (qMRI), which provides physical measures that are sensitive to structural alterations. However, a major challenge in brain research is to relate physical estimates to their underlying biological sources. In this talk, I will discuss the community's efforts to use qMRI to identify biological processes that underlie changes in brain tissue. Specifically, I will highlight approaches for differentiating between changes in the concentration and composition of myelin and iron during aging. By exploring the molecular landscape of the aging and neurodegenerative brain using qMRI, we aim to gain a better understanding of these processes and potentially provide new metrics for evaluating them.