3. Catecholamine-Driven Low-Dimensional Brain Dynamics and Cognitive Task Performance

COEX 

Cognitive flexibility underlies our ability to adapt to new and unexpected conditions in our environment. Genetic variations, such as the COMT Val158Met polymorphism, are known to influence this executive function. This study investigates the effects of the COMT genotype and the administration of tolcapone, a COMT inhibitor, on cognitive flexibility, utilizing fMRI and novel large-scale dynamic system analysis to explore underlying neural mechanisms (shine et al,. 2016; Munn et all., 2021).