Functional gradients of striatum and its linkage with frontal cortical function in cocaine addiction

COEX 

Dysregulated striatal function and executive control deficits are typically characterized in the development and perpetuation of cocaine addiction, as evidenced by animal models and human neuroimaging studies. Recently, connectome gradient-based approaches have emerged as a promising alternative to traditional parcellation-based methods for indicating continuous variations in neural organization across cortical and subcortical systems. These approaches pose huge potential in offering a novel perspective on elucidating dysfunction of striatum in cocaine addiction. Here we systematically examined the abnormalities of intra-striatal and striatal-cerebral cortex functional connectome gradient in cocaine users and revealed the effect of repetitive transcranial magnetic stimulation (rTMS) on striatal function, to facilitate the understanding about functional connectome hierarchy of striatum in cocaine addiction and treatment targets.