Plasma proteomics identifies proteins and pathways associated with incident depression

COEX 

Depression, a growing global concern with a prevalence surpassing 5%(Collins, Patel et al. 2011), gravely impairs the wellbeing and quality of life of affected individuals and posing substantial societal burdens(Herrman, Patel et al. 2022). The limited success in achieving consistent remission is intricately linked to our incomplete understanding of its pathogenesis(Yuan, Yang et al. 2023). Unraveling these elusive mechanisms is paramount, setting the stage for more effective therapeutic interventions.
While several studies have delved into the association between plasma proteins and depression(Zhang, Guo et al. 2022), their insights, albeit valuable, are constrained by small sample sizes or limited proteomic scope. Thus, it is crucial to explore the profiling protein dysregulations prior to depression onset using large biobanks. Besides, given that depression arises from a sophisticated interplay of biological and environmental elements(Yuan, Yang et al. 2023), examining these proteins within diverse biological and environmental factors and understanding their linked pathways is essential.