Alterations in functional network dynamics following ketamine treatment in major depression

COEX 

Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, produces rapid antidepressant effects in major depressive disorder (MDD). Recent investigations show that patients with MDD exhibit altered resting brain network dynamics that manifest as increased transitions between the central executive (CEN) and default mode (DMN) networks(Belleau et al., 2022), and increased dwell time in fronto-insular brain networks, which associate with rumination(Kaiser et al., 2019). We thus used Co-Activation Pattern (CAP) analysis(Liu et al., 2013) to determine how ketamine affects the dynamic properties of resting brain networks and the relationships with therapeutic effects in patients with treatment resistant depression (TRD).