Deciphering the Dynamic Spatiotemporal Maturation from Childhood to Adolescence

COEX 

Cortical maturation from childhood to adolescence plays a crucial role in neurodevelopment, shaping cognition, emotions, and behaviors. Convergent evidence suggests that neurodevelopment proceeds in a hierarchical manner, with heterogeneous structural and functional maturation patterns. However, the relationship between the established static functional patterns and the brain's intrinsic spatiotemporal dynamics remains underexplored. To address this gap, we employ Complex Principal Component Analysis (CPCA), a technique capable of reducing the complexity of high-dimensional spatiotemporal data on multiple development datasets. In this study, we aim to understand how spatiotemporal patterns develop with age, both locally and globally, focusing on three distinct propagation pathways from childhood to adolescence.