In vivo mapping of cortical excitation-inhibition imbalance in temporal lobe epilepsy

COEX 

Excitation-inhibition (E:I) imbalance is posited as a fundamental pathophysiological mechanism in temporal lobe epilepsy (TLE).[1] However, previous evidence supporting this hypothesis has been primarily derived from experimental studies in non-human animals. This study aims to non-invasively elucidate the cortical pattern of E:I imbalance in TLE patients and explore its associations with disease severity and cognitive impairment.