Novel functional network-level glymphatic clearance associated with network connectivity in human

COEX 

How brain extraordinary activity coordinates its complex clearance system is a fundamental question in systems neuroscience (Yeo BT et al., 2011; Mollon JD et al., 2022). Serving a role in waste clearance, glymphatic system is critical to brain health and cognitive performance (Hablitz LM et al., 2021). But how it relates with functional network within cortical regions remains elusive. Moreover, non-invasive regional assessment for glymphatic system is lacking (Kamagata K et al., 2021). Therefore, we aimed to unravel the characteristics of network-level glymphatic function and validate a potential regional assessment (i.e., free-water) for glymphatic clearance. We further explore whether network-level glymphatic clearance was integrated with network connectome.