Quantifying bundles

COEX 

Tractography enables quantitative mapping of the brain’s structural connectivity using measures of connectivity or tissue microstructure. This presentation will provide a high-level overview of how tractography is used to perform quantitative analysis in health and disease. We will describe two main types of quantitative analyses of tractography, including: 1) tract-specific analysis that is typically hypothesis-driven and studies particular anatomical fiber tracts, and 2) connectome-based analysis that is often data-driven and generally studies the structural connectivity of the entire brain. We highlight three main processing steps that are common across most approaches for quantitative analysis of tractography, including methods for tractography correction, segmentation, and quantification. We then show example studies that have used these quantitative tractography approaches to study the brain’s white matter.