Traditional high-field MRI (>1.5T) requires large and expensive scanners, supported by cryogenics and shielding. Recently, a 64mT portable ultra-low-field MRI scanner became commercially available, which runs using a standard electrical socket. This enables scanning at the bedside, out in the field, and in low- and middle-income countries (LMICs) with limited access to high-field MRI.
This symposium will showcase the transformative potential of ultra-low-field MRI. We will first showcase the test-retest reliability of 64mT ultra-low-field MRI, and its correspondence to 3T high-field MRI, in a dataset of healthy adult participants (due to be made openly available). We will next demonstrate the relevance of portable MRI to study early neurodevelopment in LMICs. We will present results from a pilot randomized controlled trial in Uganda investigating the impact of a once-daily nutritional formula supplement on brain growth and global scales for early development (GSED) scores at 3, 6 and 12 months of age. We will also showcase a longitudinal study of 250 mother-infant dyads in Pakistan, aiming to assess neurodevelopment from early infancy (1 month) to 3.5 years and its association to modifiable environmental factors such as early child nutrition and maternal stress. Finally, we will share insights from an ultra-low-field MRI scanner that has been on the road for six months, within a mobile laboratory which also includes cognitive testing, genomics and other “mobile-ready” phenotyping approaches.
Taken together, symposium participants will learn about the timeliness and importance of ultra-low-field MRI for widening accessibility to neuroimaging in diverse contexts.
● Awareness of the potential of ultra-low-field MRI
● Relevance of ultra-low-field scanners for widening access to MRI in low- and middle-income countries
● Practical insights into MRI scanning in a mobile laboratory
Any researcher or clinician, of any seniority, with an interest in magnetic resonance imaging.
Ultra-low-field MRI scanners offer a cost-effective and portable alternative to high-field neuroimaging. We aimed to quantify between-scanner test-retest reliability of 64mT brain scans, and their correspondence to 3T MRI. We scanned 23 healthy adult participants on two Hyperfine 64mT scanners and a GE 3T scanner using T1w and T2w scans at multiple resolutions. We segmented all images into 98 structures and estimated their volumes. We demonstrate excellent reliability of volumetric estimates from ultra-low-field MRI, and high correspondence to high-field scans. The highest reliability and high-field correspondence was obtained using T2w ultra-low-field scans, super-resolved by combining three orthogonal acquisitions with low through-plane resolution. This enables quantitative analysis of cost-effective and portable neuroimaging in various contexts, including low-resource environments.
, King's College London
Infant growth impairment is common in LMICs and is associated with impaired school readiness and potentially reduced human capital. In a pilot randomized controlled trial, we investigated the effect of a once-daily, fixed small-volume of formula supplementation on: (1) Brain growth, i.e., total brain volume, white matter volume and gray matter volume as visualized by ultra-low-field MRI at 3, 6 and 12 months of age; and (2) Global scales for early development (GSED) scores. We also explored the relationship between ultra-low-field MRI findings and GSED scores.
The study aims to map child growth and neurodevelopment trajectories from early infancy (1 month) to 3.5 years in Karachi, Pakistan, using longitudinal MRI scans and neurodevelopmental assessments. The secondary goal is to explore relationships between modifiable environmental factors (e.g., early child nutrition, maternal stress) and evolving brain structure, function, and cognitive skills.
This longitudinal cohort study includes 250 mother-infant dyads divided into three groups based on infant age: Group 1 (1 month), Group 2 (3 months), and Group 3 (6 months). High Field MRI (3T) was performed on all participants, and ultra-low-field MRI was performed on 63 participants.
Neuroimaging data analyses include estimation of brain tissue volume, thickness and surface area, and subsequent correlation with neurocognitive assessments (GSED, RIAS, etc.) conducted at predetermined intervals, as well as associations with maternal and child health (micronutrient levels in blood and breast milk).
, Aga Khan University Karachi
In this presentation; Dr. Huentelman will discuss the following topics:
(1) the use of internet-based recruitment and study of cognition to enhance cohort size and diversity,
(2) the development of a mobile research laboratory to facilitate ease of research participation by underserved participants,
(3) the current and emerging remote and mobile phenotyping approaches that integrate effectively in a mobile laboratory
(4) the first preliminary glance at a multi-faceted research study utilizing a mobile laboratory that has been on the road for six months including low-field MRI, cognitive testing, genomics, and other "mobile-ready" phenotyping approaches.
, The Translational Genomics Research Institute Phoenix, AZ