Multiphenotype analysis of hippocampal subfields revealed novel signatures associated with a higher genetic risk of Alzheimer’s disease.

COEX 

Brain Imaging Genetic studies investigate genetic influences on brain structure and function by integrating neuroimaging-based features and genetic data. While many studies focus on individual genetic correlations with single brain measurements, the field emphasizes the necessity of multivariate methods. This presentation will highlight the significance of multivariate methodologies in the realm of brain Imaging Genetic studies. As a proof of concept, we will show a detailed analysis showcasing how genetic predisposition to Alzheimer's disease impacts the joint modulation of hippocampal subfields volumes. A comparative analysis with results from univariate approaches will underscore the pivotal role of multivariate methodologies in unraveling the genetic influences on brain imaging.