Biological decoding of functional dysconnectivity via cross-species fMRI

COEX 

Silvia Gini (Italy) will present recent cross-species investigations of the molecular and physiological mechanisms underlying fMRI dysconnectivity in brain disorders. Specifically, she will show how genetic manipulations across multiple murine models of brain disorders can be used to uncover the molecular pathways underpinning fMRI hyper- and hypo-connectivity patterns identified in clinical populations. She will then illustrate how applying a multiscale approach in cross-species samples can help us uncover biological bases of fMRI dysconnectivity, linking it to alterations in synaptic processes. A discussion of how this framework may offer novel opportunities to biologically decode fMRI dysconnectivity in human disorders will follow.