Functional Connectome Dynamics - Slow, Fast, or Both?

COEX 

The dominance of fMRI as the primary lens through which the functional connectome is studied has led to the implicit assumption that the connectome constitutes a single stream of time-varying connectivity patterns. However, a multi-modal approach challenges this view. Specifically, source-space EEG-derived connectivity in a large cohort demonstrates that sub-second connectome dynamics are methodologically reliable, individually specific, highly heritable, and predictive of cognitive abilities. Sadaghiani will argue that these rapid dynamics are neurally largely distinct from the dynamics observed in fMRI. This conclusion is derived from concurrently recorded source-localized scalp EEG-fMRI and human intracranial EEG-fMRI. Specifically, spatially similar connectome states (recurrent connectivity patterns) are found in fMRI and all EEG frequency bands, but these states occur at different timepoints in fMRI and each EEG band. This multiplex of temporally distinct but parallel connectome trajectories can enable concurrent communication across multiple sets of brain regions in an independent manner.