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Right Caudate Nucleus is an Important Imaging Biomarker of Schizophrenia

Poster No:

373 

Submission Type:

Abstract Submission 

Authors:

Yushu Zhou1,2,3, Xuzhen Liu1,2,3, Kang Liu1,2,3, Xue Li1,2,3, song liu1,2,3, Anran Chen1,2,3, Weiyi Han1,2,3, Xiaoyue Duan1,2,3, Wenqiang Li1,2,3, Luxian Lv1,2,3, Yongfeng Yang1,2,3

Institutions:

1Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China, 2Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, China, 3Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder, Xinxiang, China

First Author:

Yushu Zhou  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Co-Author(s):

Xuzhen Liu  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
Kang Liu  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
Xue Li  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
song liu  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
Anran Chen  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
Weiyi Han  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
Xiaoyue Duan  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
Wenqiang Li  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
Luxian Lv  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China
Yongfeng Yang  
Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Introduction:

Schizophrenia (SZ) presents with a variety of clinical symptoms, and the treatment and prognosis differ between patients with prominent positive symptoms and those with prominent negative symptoms. However, there is a lack of research on the pathological mechanisms underlying the brain differences between SZ with prominent positive symptoms, SZ with prominent negative symptoms, and healthy controls (HC). In this study, we used amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and functional connectivity (FC) for analysis, aiming to compare the functional differences in brain regions among the three groups of subjects and to explore the imaging mechanisms behind the occurrence of different symptoms in SZ.

Methods:

This study recruited 38 HC, 38 SZ with prominent negative symptoms(SZ-Ⅰ), and 39 SZ with prominent positive symptoms(SZ-Ⅱ) from the Second Affiliated Hospital of Xinxiang Medical University and surrounding communities. Data were preprocessed using dpabi, and single-factor analysis of variance with SPM(Statistical Parametric Mapping) was performed to compare ALFF, fALFF, and ReHo values among the three groups to identify brain regions with differences. Based on the brain regions that showed differences across all three groups, we calculated FC to the whole brain at the voxel level and used single-factor ANOVA to compare FC among the three groups, further analyzing the correlation between the functions of the differential brain regions and cognitive functions.

Results:

The fALFF values in the right caudate nucleus of SZ-Ⅰ were significantly higher than those of HC, and those of SZ-Ⅱ were significantly higher than those with prominent negative symptoms, with significant differences observed among all three groups (FDR corrected, F=20.2428). The ReHo values in the right caudate nucleus also showed differences among the three groups (FDR corrected, F=16.9499). In SZ-Ⅱ, there was a correlation between the fALFF values in the right caudate nucleus and the maze scores (p=0.034, r=-0.388, FDR=0.34). In SZ-Ⅰ, there was a correlation between the fALFF values in the right caudate nucleus and the spatial span scores (p=0.010, r=-0.479, FDR=0.10).
Supporting Image: Figure1.png
Supporting Image: Figure2.png
 

Conclusions:

The right caudate nucleus is a brain region that shows significant differences between SZ-Ⅰ, SZ-Ⅱ, and HC. The right caudate nucleus is an important imaging biomarker of SZ, and this study may provide a deeper understanding of the pathophysiological mechanisms of different subtypes of SZ.

Disorders of the Nervous System:

Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1

Modeling and Analysis Methods:

fMRI Connectivity and Network Modeling 2

Novel Imaging Acquisition Methods:

BOLD fMRI
Multi-Modal Imaging

Keywords:

FUNCTIONAL MRI
Schizophrenia
Other - Positive Symptoms; Negative Symptoms; Right Caudate Nucleus

1|2Indicates the priority used for review

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Functional MRI

For human MRI, what field strength scanner do you use?

3.0T

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