Print Close

Longitudinal rs-fMRI changes reveal local brain function in patients with schizophrenia

Poster No:

374

Submission Type:

Abstract Submission

Authors:

Xiaoyue Duan¹^,2^,3, song liu¹^,2^,3, Kang Liu¹^,2^,3, Xue Li¹^,2^,3, Xuzhen Liu¹^,2^,3, Anran Chen¹^,2^,3, Weiyi Han¹^,2^,3, Yushu Zhou¹^,2^,3, yong han¹^,2^,3, Luxian Lv¹^,2^,3, Wenqiang Li¹^,2^,3, Yongfeng Yang¹^,2^,3

Institutions:

¹Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China, ²Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, China, ³Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder, Xinxiang, China

First Author:

Xiaoyue Duan
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Co-Author(s):

song liu
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Kang Liu
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Xue Li
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Xuzhen Liu
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Anran Chen
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Weiyi Han
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Yushu Zhou
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

yong han
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Luxian Lv
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Wenqiang Li
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Yongfeng Yang
Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University|Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, International Joint Research Laboratory for Psychiatry and Neuroscience of Henan|Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder
Xinxiang, China|Xinxiang, China|Xinxiang, China

Introduction:

Schizophrenia (SZ) is a serious psychiatric disorder that affects 1% of the world's population and the main symptoms can be classified as positive, negative, and general psychopathology symptoms[1]. Regional brain function is measured by assessing ALFF, fALFF, and ReHo . These 3 voxel-based metrics define brain functional characteristics from different perspectives and show a progressive relationship that allows for more sensitive identification of regional abnormalities. A reliable brain atlas reflecting this subdivision is essential to quantitatively investigate the functional and structural characteristics of the human brain. We used Brainnetome Atlas[2] to investigate the changes in rs-fMRI indicators before and after treatment in SZ patients and their association with symptoms and cognitive function.

Methods:

This study recruited 109 patients with SZ from the Second Affiliated Hospital of Xinxiang Medical University. Collect their baseline and 8-week post-treatment imaging, PANSS and MATRICS consensus cognitive test (MCCB) data. The patient meets the clinical diagnostic criteria for SZ in DSM-IV of the United States, and is confirmed by two attending physicians or more psychiatrists. Preprocess the original image of the patient, and then calculate individual ALFF, fALFF, and ReHo to evaluate functional activity. Statistical analysis was conducted using Matlab2020a, and statistical charts were conducted using PyCharm software based on Python. All continuous variables are represented by the mean SD. Map the resting fMRI indicators (ALFF, fALFF, and ReHo) calculated by SZ patients to Brainnetome Atlas in Matlab software, and extract the mean values of each brain region in the map for analysis. To determine the differences in resting fMRI indicators between baseline and 8-week treatment patients, we used paired sample t-tests for analysis and performed Bonferroni correction on the results. Then, Pearson correlation analysis was performed on the baseline resting fMRI indicators of brain regions that underwent changes after treatment with PANSS reduction rate, Spearman correlation analysis was performed on MCCB reduction rate (MCCB reduction rates did not conform to normal distribution), and Bonferroni correction was performed on the results.

Results:

After 8 weeks of treatment, increased ALFF was seen in the frontal and parietal lobes, insula gyrus, cingulate gyrus, and basal ganglia, while it decreased in the temporal and occipital lobes. fALFF increased in the temporal lobe, cingulate gyrus, basal ganglia, and thalamus, but decreased in the frontal, temporal, parietal, and occipital lobes. ReHo increased in the frontal lobe and decreased in the frontal, temporal, parietal, insular gyrus, and occipital lobes (Figure 1). As shown in Figure 2, the baseline fALFF in the mOccG_r subregion correlated positively with MCCB's sign encoding and word learning score reduction (r=0.30, p=0.039), the ReHo in A9_46d_l subregion correlated negatively with PANSS's positive factors reduction (r=-0.36, p=0.0033), and the A8vl_1 region correlated negatively with PANSS's general symptom factors reduction (r=-0.31, p=0.028). Additionally, the A37mv_r subregion in the temporal lobe and the rLinG_r subregion in the occipital lobe both showed positive correlations with MCCB's sign code reduction (r=0.32, p=0.032 and r=0.33, p=0.023, respectively).

Conclusions:

This study found that the brain regions with functional changes before and after treatment mainly focused on the frontotemporal and occipital lobes. The two subregions of the frontal gyrus were negatively correlated with the reduction rates of positive and general symptoms respectively, while those of the occipital lobe were positively correlated with word learning and symbol encoding in MCCB. These findings offered new evidence for the hypothesis of abnormal SZ functional activity and potential neurobiological objective indicators for clinical diagnosis and efficacy prediction.

Disorders of the Nervous System:

Psychiatric (eg. Depression, Anxiety, Schizophrenia) ¹

Modeling and Analysis Methods:

Connectivity (eg. functional, effective, structural)

fMRI Connectivity and Network Modeling ²

Neuroinformatics and Data Sharing:

Brain Atlases

Keywords:

Cognition

FUNCTIONAL MRI

Schizophrenia

Other - regional homogeneity,amplitude of low-frequency fluctuations, symptom,

^1|2Indicates the priority used for review

Abstract Information

By submitting your proposal, you grant permission for the Organization for Human Brain Mapping (OHBM) to distribute your work in any format, including video, audio print and electronic text through OHBM OnDemand, social media channels, the OHBM website, or other electronic publications and media.

I accept

The Open Science Special Interest Group (OSSIG) is introducing a reproducibility challenge for OHBM 2025. This new initiative aims to enhance the reproducibility of scientific results and foster collaborations between labs. Teams will consist of a “source” party and a “reproducing” party, and will be evaluated on the success of their replication, the openness of the source work, and additional deliverables. Click here for more information. Propose your OHBM abstract(s) as source work for future OHBM meetings by selecting one of the following options:

I am submitting this abstract as an original work to be reproduced. I am available to be the “source party” in an upcoming team and consent to have this work listed on the OSSIG website. I agree to be contacted by OSSIG regarding the challenge and may share data used in this abstract with another team.

Please indicate below if your study was a "resting state" or "task-activation” study.

Resting state

Healthy subjects only or patients (note that patient studies may also involve healthy subjects):

Patients

Was this research conducted in the United States?

Were any human subjects research approved by the relevant Institutional Review Board or ethics panel? NOTE: Any human subjects studies without IRB approval will be automatically rejected.

Yes

Were any animal research approved by the relevant IACUC or other animal research panel? NOTE: Any animal studies without IACUC approval will be automatically rejected.

Not applicable

Please indicate which methods were used in your research:

Functional MRI

For human MRI, what field strength scanner do you use?

3.0T

Which processing packages did you use for your study?

SPM

Provide references using APA citation style.

[1]Jauhar S, Johnstone M, McKenna P J. Schizophrenia[J]. Lancet 2022; 399:473-486.
[2]Fan L, Li H, Zhuo J, Zhang Y, Wang J, Chen L, et al. The human brainnetome atlas: A new brain atlas based on connectional architecture[J]. Cereb Cortex 2016; 26:3508-3526.

UNESCO Institute of Statistics and World Bank Waiver Form

I attest that I currently live, work, or study in a country on the UNESCO Institute of Statistics and World Bank List of Low and Middle Income Countries list provided.