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Age of onset, brain controllability and Working Memory performance in first-episode schizophrenia

Poster No:

381

Submission Type:

Abstract Submission

Authors:

Jie Yang¹

Institutions:

¹Second Xiangya Hospital of Central South University, Changsha, Hunan

First Author:

Jie Yang
Second Xiangya Hospital of Central South University
Changsha, Hunan

Introduction:

The age of onset of schizophrenia introduces considerable heterogeneity in cognitive functions such as working memory among patients. One of the key properties of the brain that varies with age-related development is the network-level controllability of brain state transitions. We tested the effect of onset-age on brain controllability to evaluate its impact on working memory deficits in schizophrenia.

Methods:

We examined the average and modal controllability of the brain connectome in 85 first-episode early-onset schizophrenia (EOS), 62 matched younger healthy controls (yHC), 71 first-episode adult-onset schizophrenia (AOS), and 85 matched older healthy controls (oHC) during N-back tasks. In a whole-brain search, we first detected the regions with illness and onset-age interaction. Then we conducted a correlation analysis with working memory performance and clinical characteristics, followed by an out-of-sample gene annotation analysis.

·Scheme of analysis

Results:

We detected the illness/onset-age interaction in the sensorimotor network, auditory network, and subcortical network for average controllability and in the default mode network, visual network, and salience network for modal controllability (p-fdr<0.05). The interaction effects in the visual and subcortical networks primarily resulted from the AOS vs. oHC differences; the effects in the default mode network resulted from EOS vs. yHC differences. We observed no significant correlation between controllability and cognitive performance or clinical characteristics. The affected regions had preferential expression of genes relevant to synaptic signaling and neurodegenerative processes (p-fdr<0.05).

·Brain regions with illness and onset-age interaction effects on controllability during‘2-back' load across all groups.

Conclusions:

Onset-age introduces considerable heterogeneity in the controllability of brain state transition during working memory tasks among patients with schizophrenia.

Disorders of the Nervous System:

Psychiatric (eg. Depression, Anxiety, Schizophrenia) ¹

Learning and Memory:

Working Memory ²

Lifespan Development:

Early life, Adolescence, Aging

Modeling and Analysis Methods:

fMRI Connectivity and Network Modeling

Novel Imaging Acquisition Methods:

BOLD fMRI

Keywords:

Other - Psychosis; Neurocognition; Connectome; Neurodevelopment; Neurodevelopment

^1|2Indicates the priority used for review

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Were any human subjects research approved by the relevant Institutional Review Board or ethics panel? NOTE: Any human subjects studies without IRB approval will be automatically rejected.

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Functional MRI

For human MRI, what field strength scanner do you use?

3.0T

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