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A diffusion tensor image study on the response to electroconvulsive therapy in schizophrenia

Poster No:

382 

Submission Type:

Abstract Submission 

Authors:

Minah Kim1, Jun Soo Kwon2

Institutions:

1Seoul National University Hospital, Seoul, Republic of Korea, 2Hanyang University Hospital, Seoul, Seoul

First Author:

Minah Kim  
Seoul National University Hospital
Seoul, Republic of Korea

Co-Author:

Jun Soo Kwon  
Hanyang University Hospital
Seoul, Seoul

Introduction:

Electroconvulsive therapy (ECT) is an effective treatment for patients with treatment resistant schizophrenia spectrum disorders (SSD). However, understanding of underlying mechanisms for ECT response has not yet been sufficient in addition to lack of knowledge regarding the target for region specific neuromodulation. Therefore, we investigated thalamo-cortical white matter (WM) connectivity as an indicator of ECT response in patients with SSD.

Methods:

A total of 26 SSD patients and age-, sex-matched 28 healthy controls (HCs) underwent diffusion tensor imaging (DTI) to examine the probabilistic tractography of thalamo-cortical WM connectivity. DTI recordings were performed twice before (T1) and after (T2) the course of ECT (i.e., 1-2 months interval) in SSD group, and data were compared across time and groups (i.e., SSD vs. HCs). Relationship of change in thalamo-cortical WM connectivity and symptomatic improvement by ECT was explored in SSD patients.

Results:

At T1, SSD patients showed lower thalamo-lateral prefrontal cortex WM connectivity and higher thalamo-parietal cortex (PC) WM connectivity than in HCs. At T2, difference of thalamo-PC WM connectivity shown at T1 was disappeared between SSD patients and HCs. In SSD patients, there was significant decrease of thalamo-PC WM connectivity between T1 and T2. In addition, change in thalamo-PC WM connectivity was significantly associated with improvement in Positive and Negative Syndrome Scale total and Clinical Global Impression-Severity scores in SSD patients.
Supporting Image: 1.jpg
   ·Figure 1
Supporting Image: 2.jpg
   ·Figure 2
 

Conclusions:

The current study results suggest that decrease in thalamo-PC WM connectivity can be an indicator of ECT response in SSD patients. Furthermore, PC may be a future target for region specific neuromodulation in patients with treatment resistant SSD.

Brain Stimulation:

Non-invasive Electrical/tDCS/tACS/tRNS 2

Disorders of the Nervous System:

Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1

Keywords:

MRI
Schizophrenia
Thalamus
Tractography
Other - electroconvulsive therapy

1|2Indicates the priority used for review

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Were any human subjects research approved by the relevant Institutional Review Board or ethics panel? NOTE: Any human subjects studies without IRB approval will be automatically rejected.

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Please indicate which methods were used in your research:

Diffusion MRI

For human MRI, what field strength scanner do you use?

3.0T

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