Poster No:
383
Submission Type:
Abstract Submission
Authors:
Zhenzhong Zhong1, Isidoor Bergfeld1, Bart Kwaasteniet2, Judy Luigjes1, Jan van Laarhoven3, Peter Notten3, Guus Beute4, Pepijn van den Munckhof5, Rick Schuurman5, Damiaan Denys6, Guido van Wingen6
Institutions:
1University of Amsterdam, Amsterdam, North Holland, 2Isala Hospital, Department of Radiology and Nuclear Medicine, the Netherlands, Zwolle, Overijssel, 3Department of Psychiatry, ETZ, location Elisabeth, Tilburg, Noord-Brabant, 4Department of Neurosurgery, ETZ, location Elisabeth, Tilburg, Noord-Brabant, 5Amsterdam UMC location University of Amsterdam, Department of Neurosurgery, Amsterdam, North Holland, 6Amsterdam UMC location University of Amsterdam, Department of Psychiatry, Amsterdam, North Holland
First Author:
Co-Author(s):
Bart Kwaasteniet
Isala Hospital, Department of Radiology and Nuclear Medicine, the Netherlands
Zwolle, Overijssel
Judy Luigjes
University of Amsterdam
Amsterdam, North Holland
Jan van Laarhoven
Department of Psychiatry, ETZ, location Elisabeth
Tilburg, Noord-Brabant
Peter Notten
Department of Psychiatry, ETZ, location Elisabeth
Tilburg, Noord-Brabant
Guus Beute
Department of Neurosurgery, ETZ, location Elisabeth
Tilburg, Noord-Brabant
Pepijn van den Munckhof
Amsterdam UMC location University of Amsterdam, Department of Neurosurgery
Amsterdam, North Holland
Rick Schuurman
Amsterdam UMC location University of Amsterdam, Department of Neurosurgery
Amsterdam, North Holland
Damiaan Denys
Amsterdam UMC location University of Amsterdam, Department of Psychiatry
Amsterdam, North Holland
Guido van Wingen
Amsterdam UMC location University of Amsterdam, Department of Psychiatry
Amsterdam, North Holland
Introduction:
Deep brain stimulation (DBS) targeting the ventral anterior limb of the internal capsule (vALIC) shows potential as treatment for treatment resistant depression (TRD). While DBS alters brain function, it is not yet known whether it also induces anatomical alterations. Here we investigated the long-term effects of vALIC DBS on brain structure using structural magnetic resonance imaging.
Methods:
We included data from twelve patients with TRD before DBS surgery and after DBS parameter optimization, and from sixteen matched healthy controls at a comparable time interval to control for test-retest effects. To investigate the short-term effects of DBS deactivation after parameter optimization, thirteen patients were additionally scanned after double-blind periods of active and sham stimulation. Voxel-based morphometry analysis was used to identify volumetric differences.
Results:
The group x time interaction showed significant changes in anterior thalamic gray matter volume, with a relative reduction in TRD patients compared to controls. Follow-up analysis suggested that this was related to larger thalamic volume at baseline in DBS non-responders. A direct comparison between responders and non-responders showed an additional interaction in the posterior thalamus and hippocampus, which was also related to larger volumes at baseline in non-responders. The comparison between active and sham stimulation during the crossover phase did not show significant differences.
Conclusions:
These results show that long-term vALIC DBS is associated with a reduction in thalamic volume compared to healthy controls, suggesting that long-term DBS induces focal structural plasticity.
Brain Stimulation:
Deep Brain Stimulation 2
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Keywords:
Other - Treatment Resistant Depression, Internal Capsule, Deep Brain Stimulation, Voxel-based morphometry
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Other
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Patients
Was this research conducted in the United States?
No
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
NOTE: Any human subjects studies without IRB approval will be automatically rejected.
No
Were any animal research approved by the relevant IACUC or other animal research panel?
NOTE: Any animal studies without IACUC approval will be automatically rejected.
Not applicable
Please indicate which methods were used in your research:
Structural MRI
For human MRI, what field strength scanner do you use?
1.5T
Which processing packages did you use for your study?
SPM
Provide references using APA citation style.
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