Cortico-striatal structural connectivity and functional outcome in clinical high risk for psychosis
Poster No:
393
Submission Type:
Abstract Submission
Authors:
Eugenie Choe1, Hyungyou Park2, Jiseon Jang1, Minah Kim1, Jun Soo Kwon3
Institutions:
1Seoul National University Hospital, Seoul, Seoul, 2Seoul National University College of Natural Sciences, Seoul, Korea, Republic of, 3Hanyang University Hospital, Seoul, Seoul
First Author:
Co-Author(s):
Introduction:
Dysconnectivity in the cortico-striatal pathway, central to the pathophysiology of psychosis, is known to be present also in individuals at clinical high risk (CHR) for psychosis. Considering that the cortico-striatal pathway actively matures until adulthood, and that neuroanatomical maturation is suggested to be related to functional outcomes in CHR for psychosis, longitudinal studies on the cortico-striatal structural pathway in CHR individuals are warranted.
Methods:
Diffusion-weighted imaging data were collected at baseline and 2-year follow-up from twenty-three CHR individuals and 20 healthy controls (HCs). Probabilistic tractography was performed to segment the striatum into subregions each connected to seven cortical regions. Relative connectivity between each cortical regions and associated striatal subregions was calculated. For subgroup analysis according to the functional outcome, the CHR group was divided based on modified Global Assessment of Functioning scores at follow-up.
Results:
A significant group-time interaction was found in the relative connectivity between the left orbitofrontal cortex and its associated striatal subregion, with a negative slope in CHR subjects and a positive slope in HCs. The group-time interaction in the left orbitofrontal cortico-striatal relative connectivity reached statistical significance between CHR individuals with poor functional outcomes and HCs, while that between CHR individuals with good functional outcomes and HCs did not.
·Group-time interactions in the cortico-striatal relative connectivity of the left orbitofrontal cortex.
Conclusions:
These findings indicate abnormal white matter maturation of the orbitofrontal cortico-striatal pathway in the CHR state for psychosis. In addition, abnormal neuroanatomical maturation of the orbitofrontal cortico-striatal pathway may be a prognostic marker for functional outcome in the CHR population.
·Graphical representation of the relationship between functional outcome and the cortico-striatal relative connectivity of the left orbitofrontal cortex in the CHR group.
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Modeling and Analysis Methods:
Diffusion MRI Modeling and Analysis
Neuroanatomy, Physiology, Metabolism and Neurotransmission:
White Matter Anatomy, Fiber Pathways and Connectivity 2
Keywords:
MRI
Psychiatric Disorders
Tractography
White Matter
WHITE MATTER IMAGING - DTI, HARDI, DSI, ETC
1|2Indicates the priority used for review
Abstract Information
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Provide references using APA citation style.
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