Shared resources in fMRI-representation of fear conditioning and vestibular stimulation
Poster No:
604
Submission Type:
Abstract Submission
Authors:
Martin Lotze1, Kai Klepzig1, Thomas Stephan2, Thomas Brandt2, Martin Domin3, Marianne Dieterich2
Institutions:
1Diagnostic Radiology, University Medicine Greifswald, Greifswald, Germany, 2German Center for Vertigo and Balance Disorders (DSGZ), Munich, Germany, 3Functional Imaging Unit, Diagnostic Radiology, University Medicine Greifswald, Greifswald, Germany
First Author:
Co-Author(s):
Martin Domin
Functional Imaging Unit, Diagnostic Radiology, University Medicine Greifswald
Greifswald, Germany
Functional Imaging Unit, Diagnostic Radiology, University Medicine Greifswald
Greifswald, Germany
Introduction:
Clinical and metanalytic imaging data suggest a considerable overlap between vestibular and emotional processing especially for anxiety [1]. In addition, those patients with high anxiety show a high comorbidity in vertigo syndromes [2] and tend to develop persistent postural-perceptual dizziness [3].
Methods:
We tested 28 healthy individuals in fMRI-paradigms established for (1) galvanic vestibular stimulation and (2) classical fear conditioning with a 75% pairing during the acquisition phase [4]. During the fMRI-experiment we scored for anxiety and asked to evaluate each stimulus presented for intensity of effect (1, 2) and/or probability of aversive pairing (2). Psychophysiology was monitored using skin conductance response (SCR). fMRI was conducted using a 3T Siemens Vida equipped with a 64-channel head coil by using multiband imaging (CMRR; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota). fMRI-data analysis was performed using SPM12.
Results:
We found that expectancy ratings and SCR were comparable to other data of HCs without preceding vestibular stimulation. Galvanic vestibular stimulation showed comparable results as reported in meta-analytic approaches. During fear conditioning only anterior insula, secondary somatosensory cortex (S2) and thalamus fMRI-activation was seen. A conjunction of fMRI-maps for both experimental procedures revealed bilateral insula and S2. Regression analyses showed a high positive association of left anterior insula activation during the fear extinction period with trait anxiety.
Conclusions:
Our study confirms an overlap of vestibular and fear related processing in the posterior insula and S2 (retroinsular cortex). Modulations in left anterior insula-activation during the fear-conditioning extinction phase are consistent with findings of others about associations of anxiety and anxiety scores [5].
Brain Stimulation:
Non-Invasive Stimulation Methods Other
Emotion, Motivation and Social Neuroscience:
Emotional Learning 1
Perception, Attention and Motor Behavior:
Perception: Auditory/ Vestibular 2
Keywords:
ADULTS
Emotions
FUNCTIONAL MRI
1|2Indicates the priority used for review
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[2] Eckhardt-Henn, A., Best, C., Bense, S. et al. (2008). Psychiatric comorbidity in different organic vertigo syndromes. Journal of Neurology,255:420-428.
[3] Staab, J.P. (2019) Psychiatric considerations in the management of dizzy patients. Vestibular disorders 82, 170-179.
[4] Bouton, M. E., & Moody, E. W. (2004) Memory processes in classical conditioning. Neuroscience and biobehavioral reviews 28(7), 663–674.
[5] Klepzig K., Wendt J., Teusch L., Rickert C., Kordaß B., Lotze M. (2024) Pain, stress and anxiety in temporomandibular disorders were affected by maxillar splints. Journal of Oral Rehabilitation 51(6),1025-1033.