Poster No:
402
Submission Type:
Abstract Submission
Authors:
Jiseon Jang1, Minah Kim1
Institutions:
1Seoul National University Hospital, Seoul, Republic of Korea
First Author:
Jiseon Jang
Seoul National University Hospital
Seoul, Republic of Korea
Co-Author:
Minah Kim
Seoul National University Hospital
Seoul, Republic of Korea
Introduction:
Mismatch negativity (MMN) is attenuated in early psychosis and has been studied as a predictor of prognosis (Kim et al., 2023; Kim, Lee, Yoon, Lee, & Kwon, 2018). However, its changes over time remain unclear and controversial. In our previous study, we found that MMN was further attenuated in first episode psychosis (FEP), even when clinical symptoms improved, and this was associated with cognitive decline (Lho et al., 2020). We proposed that this might reflect the progression of the underlying disease. However, previous studies on longitudinal changes of MMN in subjects at clinical high risk (CHR) for psychosis are insufficient. Two studies reported that progressive impairment of MMN was associated with the onset of psychotic disorders in CHR subjects (Lavoie et al., 2018; Tateno et al., 2021). However, another study found no progressive MMN changes in CHR subjects (Koshiyama et al., 2017). The current study aims to investigate longitudinal MMN changes in CHR subjects and its relationship to clinical and cognitive outcomes.
Methods:
A total of 24 CHR subjects and 22 healthy controls (HCs) participated in MMN recording both at baseline and follow-up. At both time points, participants were assessed for clinical symptoms using the scale of prodromal symptoms (SOPS), functional status using the global assessment of functioning (GAF), and cognitive function using trail making test, part A and B (TMT-A/B), digit span, and auditory verbal learning test (AVLT). A repeated measures two-way analysis of covariance (ANCOVA) was used to examine whether there were group differences of MMN over time between CHR and HC groups, using follow-up duration as a covariate. Pearson's correlation analysis was performed to explore relationships between MMN change and changes in clinical and neurocognitive variables over time.
Results:
At baseline, there was significant reduction in MMN amplitude at FCz electrode in CHR group compared to HCs. A repeated-measures two-way ANCOVA revealed that MMN at FCz electrode showed a significant main effect of group (F(1) = 7.248, p<0.05), but there was no significant main effect of time (F(1) = 0.299, p=0.587) nor significant group by time interaction (F(1) = 0.299, p=0.587). There was no significant correlation between MMN change and changes in clinical and neurocognitive variables.
Conclusions:
The current findings suggest that MMN impairment is a vulnerability marker for psychotic disorders in CHR subjects that does not progress over time, unlike in FEP patients. Progressive MMN impairment may be associated with the onset of psychosis or disease progression after the onset of psychotic disorders. Future studies with a larger sample size are warranted to confirm the results of this study.
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Novel Imaging Acquisition Methods:
EEG 2
Keywords:
Electroencephaolography (EEG)
Psychiatric
Psychiatric Disorders
Schizophrenia
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Task-activation
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Patients
Was this research conducted in the United States?
No
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
NOTE: Any human subjects studies without IRB approval will be automatically rejected.
Yes
Were any animal research approved by the relevant IACUC or other animal research panel?
NOTE: Any animal studies without IACUC approval will be automatically rejected.
Yes
Please indicate which methods were used in your research:
EEG/ERP
Neuropsychological testing
Provide references using APA citation style.
1. Kim, M., Kim, T., Hwang, W. J., Lho, S. K., Moon, S.-Y., Lee, T. Y., & Kwon, J. S. (2023). Forecasting prognostic trajectories with mismatch negativity in early psychosis. Psychological Medicine, 53, 1489–1499.
2. Kim, M., Lee, T. H., Yoon, Y. B., Lee, T. Y., & Kwon, J. S. (2018). Predicting Remission in Subjects at Clinical High Risk for Psychosis Using Mismatch Negativity. Schizophrenia Bulletin, 44, 575–583.
3. Koshiyama, D., Kirihara, K., Tada, M., Nagai, T., Koike, S., Suga, M., … Kasai, K. (2017). Duration and frequency mismatch negativity shows no progressive reduction in early stages of psychosis. Schizophrenia Research, 190, 32–38.
4. Lavoie, S., Jack, B. N., Griffiths, O., Ando, A., Amminger, P., Couroupis, A., … Whitford, T. J. (2018). Impaired mismatch negativity to frequency deviants in individuals at ultra-high risk for psychosis, and preliminary evidence for further impairment with transition to psychosis. Schizophrenia Research, 191, 95–100.
5. Lho, S. K., Kim, M., Park, J., Hwang, W. J., Moon, S.-Y., Oh, S., & Kwon, J. S. (2020). Progressive Impairment of Mismatch Negativity Is Reflective of Underlying Pathophysiological Changes in Patients With First-Episode Psychosis. Frontiers in Psychiatry, 11, 587.
6. Tateno, T., Higuchi, Y., Nakajima, S., Sasabayashi, D., Nakamura, M., Ueno, M., … Suzuki, M. (2021). Features of Duration Mismatch Negativity Around the Onset of Overt Psychotic Disorders: A Longitudinal Study. Cerebral Cortex, 31, 2416–2424.
No