Multiscale Structural Connectome Eigenmodes Constrain Human Brain Functional Activity
Poster No:
1388
Submission Type:
Abstract Submission
Authors:
Jie Xia1, Jiao Li1, Huafu Chen1, Wei Liao1
Institutions:
1University of Electronic Science and Technology of China, Chengdu, Sichuan
First Author:
Co-Author(s):
Introduction:
The human brain is an intricate network organized across multiple spatial scales [1,2]. Multiscale structural organization arises from complex biological mechanisms and provides the anatomical foundation for functional interactions [3,4]. However, the extent to which multiscale structural connectome constrains functional activity remains largely uncharted. Here, we deciphered the relationship between multiscale structural connectome and cortical activity using graph signal processing.
Methods:
By leveraging multimodal magnetic resonance imaging (MRI) datasets, we constructed an in vivo multiscale structural connectome model integrating features of white matter tractography, cortico–cortical proximity, and microstructural similarity [3,4]. Spontaneous and diverse task-evoked cortical activity derived from functional MRI was decomposed into a weighted linear combination of orthogonal eigenmodes of multiscale structural connectome [5]. We introduced multimodal structure-function decoupling (MSFD) to quantify the (de)coupling strength between functional activity and the underlying multiscale connectome [6,7]. Additionally, we investigated the potential neurobiological mechanism underlying these decoupling patterns.
Results:
We found that multiscale fusion connectome eigenmodes provide a more compact representation of spontaneous and task-evoked cortical activity, outperforming eigenmodes derived from any single connectome (Fig. 1). Moreover, the multimodal structure-function relationship was gradually decoupled from the primary sensorimotor areas to higher-order transmodal cortices, reflecting microscale structural features and macroscale functional hierarchies (Fig. 2).
·Fig. 1 Multiscale structural connectome eigenmodes constrain human brain activity.
·Fig. 2 The spatial pattern of multimodal structure-function decoupling (MSFD).
Conclusions:
These findings highlight that the multiscale cortical wiring diagram serves as a powerful anatomical scaffold in shaping macroscale intrinsic human brain function, further advancing our understanding of multiscale structure-function relationship.
Modeling and Analysis Methods:
fMRI Connectivity and Network Modeling 1
Methods Development 2
Novel Imaging Acquisition Methods:
Multi-Modal Imaging
Keywords:
Computational Neuroscience
Modeling
Tractography
Other - eigenmodes
1|2Indicates the priority used for review
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Was this research conducted in the United States?
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel? NOTE: Any human subjects studies without IRB approval will be automatically rejected.
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