Poster No:
611
Submission Type:
Abstract Submission
Authors:
KAZUYA MOTOMURA1, Yuji Kibe1, Koichi Mitsuya2
Institutions:
1Shizuoka Cancer Center, Nagaizumi-cho, Shizuoka, 2Nagaizumi-cho, Shizuoka Cancer Center, Shizuoka
First Author:
Co-Author(s):
Yuji Kibe
Shizuoka Cancer Center
Nagaizumi-cho, Shizuoka
Introduction:
Patients with diffuse frontal gliomas often present with postoperative apathy after tumor removal. However, the association between apathy and tumor removal of gliomas from the frontal lobe remains unknown. This study aimed to investigate the factors influencing postoperative apathy after tumor removal in patients with diffuse frontal gliomas.
Methods:
We compared the demographics and clinical characteristics of patients with and without postoperative apathy in a cohort of 54 patients who underwent awake brain mapping for frontal gliomas.
Results:
The frequency of clinical parameters such as left-sided involvement, high-grade tumor types (WHO grades III, IV), main tumor location in the anterior cingulate gyrus (ACC) and/or dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) was significantly greater in the apathetic group compared to the nonapathetic group. The apathetic group scored significantly lower on neuropsychological assessments such as the Letter Fluency Test among the Word Fluency Tests than the nonpathetic group (p = 0.000). Moreover, the scores of Parts 3, and 3-1 of the Stroop test were significantly lower in the apathetic group than those in the nonapathetic group (p = 0.023, 0.027, respectively). Multivariate model analysis revealed that the appearance of postoperative apathy was significantly related to side of the of lesion [left vs. right, hazard ratio (HR) = 8.00, 95% confidence interval (CI) = 1.36–46.96, p = 0.021], location of the main tumor in the frontal lobe (ACC/DLPFC/OFC vs. others, HR = 7.99, 95% CI = 2.16–29.59, p = 0.002), and the Letter Fluency Test (HR = 0.37, 95% CI = 0.15–0.90, p = 0.028). Postoperative apathy is significantly associated with ACC and/or DLPFC and OFC in the left hemisphere of diffuse frontal gliomas.
Conclusions:
Apathy in frontal gliomas is correlated with a decline in the Letter Fluency Test scores. Therefore, this instrument is a potential predictor of postoperative apathy in patients with diffuse frontal gliomas undergoing awake brain mapping.
Emotion, Motivation and Social Neuroscience:
Emotional Perception 1
Social Cognition 2
Keywords:
Cognition
Emotions
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Other
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Patients
Was this research conducted in the United States?
No
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
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Yes
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Not applicable
Please indicate which methods were used in your research:
Structural MRI
Neuropsychological testing
For human MRI, what field strength scanner do you use?
3.0T
Provide references using APA citation style.
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No