A fMRI study on oral motor and sentence comprehension in Parkinson's disease
Poster No:
145
Submission Type:
Abstract Submission
Authors:
Ehsan Hemmati1, Mohammad-Reza Nazem-Zadeh2, Alireza Fallahi3, Laila Alibiglou4
Institutions:
1Iran university of medical sciences, Tehran, Tehran, 2Monash University, Melbourne, VIC, 3Hamedan University of Technology, Hamedan, Hamedan, 4Indiana University, Indianapolis, IN
First Author:
Co-Author(s):
Introduction:
Parkinson's Disease (PD) is a progressive neurodegenerative disorder and the most prevalent movement disorder, often accompanied by language difficulties and speech impairments. Previous studies have demonstrated that sentence processing can be impaired in PD. Based on word order and complexity, sentences are categorized into canonical and non-canonical forms. Canonical sentences adhere to typical language structures like subject-verb-object, while non-canonical sentences deviate, posing more significant comprehension challenges. Research has shown that PD patients have more difficulty processing long sentences and complex syntactic patterns, particularly non-canonical ones. However, whether the underlying neural mechanisms of language impairments in PD are similar to motor symptoms and related to cortico-striatal pathway dysfunction remains unclear.
·Results of articles using fMRI in auditory processing and articulation
Methods:
This study investigated functional changes in cortico-striatal language pathways affecting sentence comprehension and oral motor function in people with PD compared to neurologically healthy individuals. Using functional magnetic resonance imaging (fMRI), cortical-striatal pathways' activation levels and effective connectivity were assessed during sentence comprehension and oral motor tasks. Twenty-four people with PD and twelve age and sex-matched healthy individuals participated in this study
·The experimental paradigm of study
Results:
In the brain activation results, comparing noncanonical to canonical sentence conditions showed decreased activation in the cortical and subcortical regions in PD compared to controls (p<0.05). During the oral motor task, PD group displayed comparable activity to controls in motor cortical areas but significantly less activity in subcortical regions (p<0.05). Employing Dynamic Causal Modeling (DCM), we assessed effective connectivity between different pathways. For sentence comprehension, PD group compared to control, showed significant reduction in effective connectivity between cortico-subcortical and subcortico-subcortical areas (p<0.05). In the oral motor task, PD group showed reduced bidirectional connectivity between cortico-cortical and cortico-subcortical regions compared to controls (p<0.05).
Conclusions:
These findings suggest that activated brain regions and language network interactions are disrupted in PD patients during sentence comprehension and oral motor tasks. The decreased cortico-cortical and cortico-striatal connections, as well as the affected language network likely contribute to the impairment in performing sentence comprehension tasks and hypokinetic dysarthria in PD.
Disorders of the Nervous System:
Neurodegenerative/ Late Life (eg. Parkinson’s, Alzheimer’s) 1
Language:
Language Comprehension and Semantics
Modeling and Analysis Methods:
Activation (eg. BOLD task-fMRI) 2
Keywords:
Cortex
FUNCTIONAL MRI
Language
Sub-Cortical
Other - Parkinson's disease
1|2Indicates the priority used for review
Abstract Information
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Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
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Provide references using APA citation style.
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