Reconcile the Heterogeneous Imaging Findings of Schizotypy to a Common Brain Network
Poster No:
1966
Submission Type:
Abstract Submission
Authors:
weichao tian1, Wenqiang Xu2, Xiya Zhao3, Gong-Jun Ji1, Kai Wang4
Institutions:
1Anhui Medical University, Hefei, Anhui Province, 2Anhui Medical University, Hefei city, China, Anhui, 3School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui, 4Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui
First Author:
Co-Author(s):
Kai Wang
Department of Neurology, The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui
Department of Neurology, The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui
Introduction:
Schizotypy is a multi-dimensional personality construct that putatively indicates an individual's liability to psychosis on a continuum between health and illness. It provides an entry point for identifying developmental pathways to psychosis. This study aimed to reconcile the heterogeneous imaging findings of schizotypy into a common network theory.
Methods:
We systematically searched neuroimaging experiments investigating the neural correlates of schizotypy in literature. The coordinates reported in these experiments were mapped to networks and tested for their common connections (Fig. 1) using a novel coordinate network mapping approach. Voxel-wise comparisons were performed by 5,000 permutation tests. A cluster-level PFWE < 0.05 (with the cluster-forming threshold at voxel-level P < 0.001) was considered statistically significant.
Results:
We identified thirty-four experiments (10 structural MRI, 9 resting-state fMRI, 15 task fMRI) revealing significant structural or functional characters in schizotypy. In total, 254 coordinates were reported in these experiments. These coordinates were heterogeneously distributed in the brain (Fig. 1A). Using coordinate network mapping, we found these coordinates have highly common connectivity (top value 79%) in the bilateral subcortical structures and insular (Fig. 1B-C). These common features were specific to schizotypy as compared to random networks (Fig. 2A). Thus, we termed the overlapping network as the shizotypal network (Fig. 1C).
The schizotypal network showed a higher spatial similairty with the schizophrenia network (identified by our group before) than control networks (here is the neurodegenerative diseases network) (Fig.2B ). The genetic and molecular mechanism of this schizotypal network were identified by explaining its spatial pattern with the networks of schizotypy-related 218 genes (Fig. 2C) and 13 neurotransmitters (Fig. 2D). More importantly, the schizotypal network was remarkably aligned with regions involving psychotic symptom remission after medication, neuromodulation, and brain lesions (Fig. 2E).
The schizotypal network showed a higher spatial similairty with the schizophrenia network (identified by our group before) than control networks (here is the neurodegenerative diseases network) (Fig.2B ). The genetic and molecular mechanism of this schizotypal network were identified by explaining its spatial pattern with the networks of schizotypy-related 218 genes (Fig. 2C) and 13 neurotransmitters (Fig. 2D). More importantly, the schizotypal network was remarkably aligned with regions involving psychotic symptom remission after medication, neuromodulation, and brain lesions (Fig. 2E).
Conclusions:
Conclusions: This study successfully reconciled the heterogeneous imaging findings into a common schizotypal network. The common mechanism between schizotypy and psychosis provides new insight into understanding the developmental path from normal to illness states
Brain Stimulation:
TMS
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 2
Modeling and Analysis Methods:
Connectivity (eg. functional, effective, structural)
Novel Imaging Acquisition Methods:
Multi-Modal Imaging 1
Keywords:
Other - Schizotypy/Schizotypy network mapping/Connectivity/Neuroimaging
1|2Indicates the priority used for review