ENIGMA-PD: Brain morphology correlates of neuropsychiatric symptoms in Parkinson’s disease
Poster No:
158
Submission Type:
Abstract Submission
Authors:
Eva van Heese1, Jiska van Wijk1, Max Laansma1, Conor Owens-Walton2, Emile d'Angremont1, Chris Vriend1,3, Tim van Balkom1,3, Henk Berendse4, Elnaz Ghasemi5, Kathleen Poston5, Ysbrand van der Werf1, Odile van den Heuvel1,3
Institutions:
1Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam, Netherlands, 2Imaging Genetics Center, University of Southern California, Los Angeles, CA, 3Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, Netherlands, 4Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Neurology, Amsterdam, Netherlands, 5Stanford University, Department of Neurology & Neurological Sciences, Stanford, CA
First Author:
Eva van Heese
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Co-Author(s):
Jiska van Wijk
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Max Laansma
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Emile d'Angremont
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Chris Vriend
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences|Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry
Amsterdam, Netherlands|Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences|Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry
Amsterdam, Netherlands|Amsterdam, Netherlands
Tim van Balkom
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences|Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry
Amsterdam, Netherlands|Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences|Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry
Amsterdam, Netherlands|Amsterdam, Netherlands
Henk Berendse
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Neurology
Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Neurology
Amsterdam, Netherlands
Ysbrand van der Werf
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences
Amsterdam, Netherlands
Odile van den Heuvel
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences|Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry
Amsterdam, Netherlands|Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences|Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry
Amsterdam, Netherlands|Amsterdam, Netherlands
Introduction:
Parkinson's disease, a neurodegenerative disorder defined by its motor symptoms, has increasingly been recognized as a disease involving non-motor features, including neuropsychiatric symptoms. Previous work has identified a smaller amygdala, hippocampus, and larger anterior cingulate cortex in relation to anxiety and depressive symptoms in Parkinson's disease (van Mierlo et al., 2015; Vriend et al., 2016). This study aims to overcome limitations of previous, small-size investigations and explore the brain morphology correlates of these neuropsychiatric symptoms in a well-powered multinational dataset from the ENIGMA-PD working group.
Methods:
We collected T1-weighted MRI and clinical data across five cohorts from Amsterdam and Stanford (total n=367, age mean±SD: 62.7±9.94, 40% female). FreeSurfer (Fischl et al., 2012) was applied to obtain cortical thickness and subcortical volumes, followed by quality assessment including visual inspection and outlier detection according to the ENIGMA-PD protocol (github.com/ENIGMA-PD/FS7). Depression and anxiety severity were assessed using the Beck Depression Inventory (range[0,40]; mean±SD: 10.58±7.46) and Beck Anxiety Inventory (range[0,43]; mean±SD: 11.26±7.99), respectively. We applied linear-mixed effects models, corrected for age, sex, ICV, and cohort, and determined significance using the FDR correction (padj<.05).
Results:
None of the correlations between brain morphology and depression or anxiety measures remained significant after FDR correction. When uncorrected (p<.05), several brain regions were thinner or smaller with increasing depression or anxiety severity (cortical: temporal, frontal, cingulate cortex; subcortical: amygdala, hippocampus, caudate nucleus, thalamus). Overall, more brain regions correlated with depression severity than with anxiety severity.
Conclusions:
This preliminary analysis shows subtle associations between brain morphology, depression, and anxiety that do not reach statistical significance. These subtle findings await further confirmation using the full dataset of the ENIGMA-PD working group, in which we aim to further explore neuropsychiatry-related brain morphometry in Parkinson's disease.
Disorders of the Nervous System:
Neurodegenerative/ Late Life (eg. Parkinson’s, Alzheimer’s) 1
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 2
Modeling and Analysis Methods:
Segmentation and Parcellation
Neuroanatomy, Physiology, Metabolism and Neurotransmission:
Cortical Anatomy and Brain Mapping
Subcortical Structures
Keywords:
Degenerative Disease
Movement Disorder
Psychiatric Disorders
Sleep
STRUCTURAL MRI
Sub-Cortical
Other - morphology
1|2Indicates the priority used for review
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2. van Mierlo, T. J., Chung, C., Foncke, E. M., Berendse, H. W., & van den Heuvel, O. A. (2015). Depressive symptoms in Parkinson's disease are related to decreased hippocampus and amygdala volume. Movement Disorders, 30(2), 245-252.
3. Vriend, C., Boedhoe, P. S., Rutten, S., Berendse, H. W., van der Werf, Y. D., & van den Heuvel, O. A. (2016). A smaller amygdala is associated with anxiety in Parkinson’s disease: a combined FreeSurfer—VBM study. Journal of Neurology, Neurosurgery & Psychiatry, 87(5), 493-500.