The Influence of Dance Intervention and Aerobic Exercise on Insular Connectivity in Schizophrenia
Poster No:
486
Submission Type:
Abstract Submission
Authors:
yuanyuan yu1, Hui He1, Gujing Li1, Yayun Liu1, Kexin Gao1, Cheng Luo1, Dezhong Yao1
Institutions:
1University of Electronic Science and Technology of China, Chengdu, China
First Author:
Co-Author(s):
Introduction:
The insula serves as a crucial node in information processing and integration, and is notably affected in schizophrenia(Wylie & Tregellas, 2010)(Shepherd et al., 2012; Sun et al., 2023). Previous studies have shown that dance training can influence insula activity in healthy individuals(Rehfeld et al., 2018)(Foster Vander Elst et al., 2023) The enhancing insula function connectivity may thus be an effective approach to improving information process in schizophrenia. Therefore, the present study aims to investigate the specific effects of dance interventions on insular function in schizophrenia patients compared with aerobic exercise.
Methods:
Thirty-two schizophrenia patients were randomly assigned to the dance group (n = 18) and the aerobic exercise group (n = 14). Both groups engaged in fifty-minute intervention three times a week for 12 weeks. The Hopkins Verbal Learning Test-Revised (HVLT-R) in MATRICS Consensus Cognitive Battery (Shi et al., 2015) was used to assess the verbal memory abilities. Physiological indicators including Cystatin C(CYS-C), Total Bilirubin(TBIL), Mean Corpuscular Hemoglobin Concentration(MCHC) were measured, and resting-state fMRI were collected at baseline and 12-week follow-up in all participants. The insula encompasses the dorsal anterior insula(dAI), the ventral anterior insula(vAI), and the posterior insula(PI)(Deen et al., 2011). Both static and dynamic function connectivity has been calculated(Damaraju et al., 2014). Repeated-measure ANOVA and correlation analysis with HVLT-R scores and physiological indicators were performed. Finally, mediation analysis was conducted to examine the relationships between intervention groups, physiological indicators, and functional connectivity.
Results:
In the static function connectivity(sFC), we found significant interaction effects between dAI and Superior Occipital gyrus , Cuneus, and Middle Temporal Gyrus. Dynamic function connectivity(dFC) exhibited a broader change, including dFC between vAI and Calcarine, and between PI and Precentral gyrus. The altered dFC also correlated with HVLT-R, MCHC, TBIL and CYS-C. Furthermore, the mediation analysis results indicated the MCHC and CYS-C partially mediated the relationship between groups and changes in dFC.
Conclusions:
The results suggest that dance intervention specifically enhances insular connectivity patterns, which is linked with improvements in verbal memory in schizophrenia patients. The observed differences between dance intervention and aerobic exercise groups in modulating insular functional connectivity may be attributable to the distinct physiological mechanisms they have induced.
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Motor Behavior:
Motor Behavior Other 2
Keywords:
Behavioral Therapy
Psychiatric
Schizophrenia
Other - dance intervention
1|2Indicates the priority used for review
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Provide references using APA citation style.
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Foster Vander Elst, O., Foster, N. H. D., Vuust, P., Keller, P. E., & Kringelbach, M. L. (2023). The Neuroscience of Dance: A Conceptual Framework and Systematic Review. Neuroscience and Biobehavioral Reviews, 150, 105197. https://doi.org/10.1016/j.neubiorev.2023.105197
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