Poster No:
868
Submission Type:
Abstract Submission
Authors:
Jing Liu1, Xianhui He2, Ying Cai3
Institutions:
1South China Normal University, Guangzhou, Guangdong, 2University of Oxford, Oxford, United Kingdom, 3Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, Zhejiang
First Author:
Jing Liu
South China Normal University
Guangzhou, Guangdong
Co-Author(s):
Xianhui He
University of Oxford
Oxford, United Kingdom
Ying Cai
Department of Psychology and Behavioral Sciences, Zhejiang University
Hangzhou, Zhejiang
Introduction:
Traditionally, the hippocampus has been viewed as crucial for long-term episodic memory rather than short-term memory storage. However, growing evidence indicates that the hippocampus also supports visual short-term memory (VSTM), particularly when maintaining fine-grained, high-resolution representations. Despite accumulating evidence for the hippocampus's involvement, the specific neural signatures of VSTM within the hippocampus remain poorly understood. One candidate is hippocampal ripples, brief high-frequency oscillations tied to memory replay. Disrupting these ripples impairs short-term spatial memory in rodents, suggesting a potential similar role in humans.
Methods:
In the current study, we utilized intracranial EEG recordings on drug-resistant epilepsy patients while they were performing a high-resolution VSTM task requiring discriminating target pictures from highly similar lures.
Results:
Our results showed that hippocampal ripple rates initially increased within the first second and then return to the baseline level during a 3-second perceptual encoding stage and remain at baseline level during the maintenance stage, implicating an activity-silent state. Moreover, hippocampal ripples ramped up across the short-term maintenance period. Critically, this ramp-up effect predicted successful VSTM.
Conclusions:
Our results suggest that electrophysiological evidence that temporally dynamic hippocampal ripples during the activity-silent maintenance period support successful VSTM.
Learning and Memory:
Working Memory 1
Learning and Memory Other 2
Keywords:
Cognition
Memory
Other - Hippocampus, Ripple
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Task-activation
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Patients
Was this research conducted in the United States?
No
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
NOTE: Any human subjects studies without IRB approval will be automatically rejected.
Yes
Were any animal research approved by the relevant IACUC or other animal research panel?
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Not applicable
Please indicate which methods were used in your research:
Neuropsychological testing
Other, Please specify
-
intracranial EEG
Which processing packages did you use for your study?
Other, Please list
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Fieldtrip
Provide references using APA citation style.
Vaz, A. P., Inati, S. K., Brunel, N., & Zaghloul, K. A. (2019). Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory. Science, 363(6430), 975–978. https://doi.org/10.1126/science.aau8956
Stokes, M. G. (2015). ‘Activity-silent’ working memory in prefrontal cortex: A dynamic coding framework. Trends in Cognitive Sciences, 19(7), 394–405. https://doi.org/10.1016/j.tics.2015.05.004
Norman, Y., Raccah, O., Liu, S., Parvizi, J., & Malach, R. (2021). Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection. Neuron, 109(17), 2767-2780.e5. https://doi.org/10.1016/j.neuron.2021.06.020
No