Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Functional Dyspepsia: An fMRI Study
Poster No:
1896
Submission Type:
Abstract Submission
Authors:
Yi Luo1, Yanan Zhao2, Jiliang Fang3, Peijing Rong1
Institutions:
1Institute Of Basic Research In Clinical Medicine,China Academy Of Chinese Medical Sciences, Beijing, China, 2Institute of Acupuncture and Moxibustion, China Academy Of Chinese Medical Sciences, Beijing, China, 3Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
First Author:
Yi Luo
Institute Of Basic Research In Clinical Medicine,China Academy Of Chinese Medical Sciences
Beijing, China
Institute Of Basic Research In Clinical Medicine,China Academy Of Chinese Medical Sciences
Beijing, China
Co-Author(s):
Yanan Zhao
Institute of Acupuncture and Moxibustion, China Academy Of Chinese Medical Sciences
Beijing, China
Institute of Acupuncture and Moxibustion, China Academy Of Chinese Medical Sciences
Beijing, China
Peijing Rong
Institute Of Basic Research In Clinical Medicine,China Academy Of Chinese Medical Sciences
Beijing, China
Institute Of Basic Research In Clinical Medicine,China Academy Of Chinese Medical Sciences
Beijing, China
Introduction:
Studies have shown that transcutaneous auricular vagal nerve stimulation (taVNS) can relieve the emotional and digestive symptoms of functional dyspepsia (FD) (Shi, 2024) (Zhu, 2021). But the brain mechanism remains unclear. The aim of this study was to explore the immediate brain function modulation effects of taVNS on FD by resting-state functional magnetic resonance (rs-fMRI).
Methods:
Thirty patients with FD and 47 healthy Controls (HCs) were enrolled in this study. The FD group received immediate (30 min) taVNS treatment and underwent rs-fMRI scan before and after the intervention, the HCs did not receive any intervention and underwent rs-fMRI scan after inclusion. Before treatment, amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fLAFF) calculations were employed to compare FD group with HC. Subsequently, the differential brain regions were selected as regions of interest (ROI) to explore voxel-based functional connectivity (FC) changes after immediate taVNS treatment.
Results:
Compare with healthy subjects, patients with FD had higher levels of ALFF in left insula and lower levels of fALFF in right postcentral gyrus. The FC of left insula and left anterior cingulate (ACC) in the FD group were elevated after immediate taVNS treatment.
Conclusions:
In FD patients, the neural activity of insula and postcentral gyrus differ from healthy subjects. The insula and ACC might be the neural target of taVNS for the treatment of FD.
Brain Stimulation:
Non-Invasive Stimulation Methods Other 2
Novel Imaging Acquisition Methods:
BOLD fMRI 1
Perception, Attention and Motor Behavior:
Perception: Pain and Visceral
Keywords:
FUNCTIONAL MRI
1|2Indicates the priority used for review
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Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Was this research conducted in the United States?
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel? NOTE: Any human subjects studies without IRB approval will be automatically rejected.
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Provide references using APA citation style.
2. Zhu, Y. (2021). Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity. American journal of physiology. Gastrointestinal and liver physiology, 320(5), G700–G711.