Neuroimaging Characteristics of Levodopa-Induced Dyskinesia in de novo Parkinson’s Disease Patients
Poster No:
1968
Submission Type:
Abstract Submission
Authors:
Sakshi Shukla1, Mantosh Patnaik1, Aditya Kumar2, Sule Tinaz3, Nivethida Thirugnanasambandam4
Institutions:
1Indian Institute of Technology (IIT) Bombay, Mumbai, Maharashtra, 2Indian Institute of Science, Education and Research (IISER), Kolkata, Kolkata, 3Yale School of Medicine, New Haven, CT, 4Indian Institute of Technology Bombay, Mumbai, Maharashtra
First Author:
Co-Author(s):
Introduction:
Levodopa-induced dyskinesia (LID) is a significant treatment complication that affects a substantial proportion of Parkinson's disease (PD) patients. Our understanding of the neural basis of LID remains limited, partly due to the small sample sizes in existing neuroimaging studies.
Methods:
In this study, we utilized structural MRI data from the Parkinson's Progression Markers Initiative (PPMI) database, including de novo PD patients (104 non-dyskinetic for a least 3 years after diagnosis and 120 who developed dyskinesia) and 100 age- and sex-matched healthy controls. Additionally, we analyzed resting-state functional MRI data from a subset of these participants to investigate connectivity differences among the groups.
·Study Pipeline
Results:
Our analysis revealed no significant baseline volumetric differences between dyskinetic and non-dyskinetic PD patients. However, the thickness of frontal and sensorimotor cortices were significantly greater in dyskinetic patients. In the subcortical regions, vertex-based shape analysis identified localized surface growth in the left caudate and left pallidum, as well as surface morphology changes in the bilateral pallidum in dyskinetics. Resting-state functional connectivity analysis revealed stronger connectivity between the putamen, inferior frontal gyrus, and sensory cortex in dyskinetic PD patients compared to non-dyskinetics.
Conclusions:
These findings suggest that specific morphological and functional changes in the motor cortical-basal ganglia circuitry of de novo PD patients may predispose them to LID over time. Additionally, the altered functional connectivity patterns reinstate the role of the inferior frontal gyrus in the pathophysiology of dyskinesia and suggest that it might be a suitable target for neuromodulatory interventions, consistent with previous reports.
·Graphical abstract
Disorders of the Nervous System:
Neurodegenerative/ Late Life (eg. Parkinson’s, Alzheimer’s) 2
Modeling and Analysis Methods:
fMRI Connectivity and Network Modeling
Segmentation and Parcellation
Novel Imaging Acquisition Methods:
BOLD fMRI
Multi-Modal Imaging 1
Keywords:
FUNCTIONAL MRI
STRUCTURAL MRI
Other - Parkinson's disease, Voxel-based morphometry, Vertex-based analysis, Levodopa-Induced Dyskinesia
1|2Indicates the priority used for review
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Provide references using APA citation style.
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