Deviated neural connectivity might predict the results of microvascular depression surgery
Poster No:
2050
Submission Type:
Abstract Submission
Authors:
Ying Wang1, Hao Chen1, Xiaofeng Jiang1
Institutions:
1The First Affiliated Hospital of USTC, HeFei, AnHui
First Author:
Co-Author(s):
Introduction:
Classic trigeminal neuralgia (TN) is an intolerable pain condition characterized by vascular compression of the trigeminal nerve. Microvascular decompression surgery (MVD) has been widely recognized as the most effective treatment option for classic TN in clinical practice (1-4). However, the variability in surgical outcomes remains poorly understood, and no definitive predictive model has been established (5-10). This study aims to explore the central nervous system mechanisms that may help distinguish between effective and ineffective MVD outcomes.
Methods:
In this study, we recruited 30 patients with classic TN who experienced complete relief following MVD surgery (E group), 30 matched patients with limited post-surgical benefits (NE group), and another 30 matched healthy controls (HC). Resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data were collected from all participants before and after MVD surgery, as well as from all healthy controls. We utilized the "recruitment" index of the fMRI data to characterize intra-communication among peer regions within the same subsystem. We then compared the E group and NE group using HC as a baseline, and assessed whether the patients' recruitment index shifted towards that of the HC post-surgery. Furthermore, we examined the underlying structural basis of functional connectivity, employing MRTrix3.0 to assess fiber quantities between brain regions and TBSS analysis to evaluate the fractional anisotropy (FA) of white matter fiber bundles.
Results:
Our findings revealed that the recruitment index of three brain regions in the E group before surgery (EB) was significantly higher than that of the NE group before surgery (NEB), with HC positioned in the middle. Notably, after surgery, the index in the E group decreased while it increased in the NE group. Additionally, the DTI results demonstrated a reduction in the strength and integrity of white matter fiber tracts in the NEB group.
Conclusions:
Our results suggest that TN may not solely be a peripheral nerve disorder, and the altered functional and structural connectivity observed may provide valuable insights into predicting the outcomes of microvascular decompression surgery for patients with classic trigeminal neuralgia.
Modeling and Analysis Methods:
Connectivity (eg. functional, effective, structural) 2
fMRI Connectivity and Network Modeling
Novel Imaging Acquisition Methods:
BOLD fMRI
Perception, Attention and Motor Behavior:
Perception: Pain and Visceral 1
Keywords:
FUNCTIONAL MRI
Pain
1|2Indicates the priority used for review
·a, Demographic and clinical data were harmonized across the three groups of trigeminal neuralgia patients. b, The VAS score change following surgery in the two groups of TN patients.
·The recruitment of the three groups and the change after the MVD surgery
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Provide references using APA citation style.
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