Poster No:
1229
Submission Type:
Abstract Submission
Authors:
JIHYE LEE1,2,3, Maithreyee Devi2,3, Aram Cho4,3, Song E Kim5, Hyang Woon Lee6
Institutions:
1Ewha Womans University Mokdong Hospital, SEOUL, Korea, Republic of, 2Computational Medicine, Ewha Womans University School of Medicine, SEOUL, Korea, Republic of, 3Computational Medicine, System Health Science & Engineering Program, Ewha Womans University, SEOUL, Korea, Republic of, 4Department of Medical Science, Ewha Womans University School of Medicine, SEOUL, Korea, Republic of, 5Ewha Womans University Mokdong Hospital, SEOUL, Seoul, 6Ewha Womans University School of Medicine, Seoul, DC
First Author:
JIHYE LEE
Ewha Womans University Mokdong Hospital|Computational Medicine, Ewha Womans University School of Medicine|Computational Medicine, System Health Science & Engineering Program, Ewha Womans University
SEOUL, Korea, Republic of|SEOUL, Korea, Republic of|SEOUL, Korea, Republic of
Co-Author(s):
Maithreyee Devi
Computational Medicine, Ewha Womans University School of Medicine|Computational Medicine, System Health Science & Engineering Program, Ewha Womans University
SEOUL, Korea, Republic of|SEOUL, Korea, Republic of
Aram Cho
Department of Medical Science, Ewha Womans University School of Medicine|Computational Medicine, System Health Science & Engineering Program, Ewha Womans University
SEOUL, Korea, Republic of|SEOUL, Korea, Republic of
Song E Kim
Ewha Womans University Mokdong Hospital
SEOUL, Seoul
Introduction:
Introduction: Although a connection between sleep disruption and cognitive deterioration has been documented, causal relationship and/or biological mechanisms need to be further clarified. The current study investigates the association between self-reported sleep quality, hippocampal regional volumes and cognitive performance. This study examines the relationships among hippocampal volume, cognitive function, and sleep quality, with a particular focus on the influence of cognitive performance on sleep quality in middle-to-old-aged general population, with the emphasis on sex differences between men and women.
Methods:
Methods: A total of 1,227 participants between the ages of 49 to 80 were enrolled in the Korean genome and epidemiology study, which provided the data for this population-based cohort study. The comprehensive evaluation was performed including biochemical, metabolic, behavioral assessment including Pittsburgh Sleep Quality Index (PSQI) for self-reported sleep quality, Beck's Depression Inventory (BDI) for depressive symptoms, neuropsychological tests for verbal and spatial memory using California verbal learning test (CVLT), Rey-Osterrieth complex figure test (RCFT), verbal fluency using Controlled Oral Word Association Test (COWAT), executive functions such as Stroop and Trail-making tests (TMT) and T1-weighted magnetic resonance imaging (MRI). This study examines the relationships among hippocampal volume, cognitive function, and sleep quality, with a particular focus on the influence of cognitive performance on sleep quality.
Results:
Results: Risk factors in cognitive decline for females are physical activity, sleep deficiency, depression, and menopausal changes. The analysis of covariance (ANCOVA) demonstrated a reduction in central cingulate cortex volume in post-menopausal compared to menopausal and pre-menopausal groups. Additionally, simple mediation model highlighted, age had direct effects on executive function tests, with indirect path via Sleep efficiency and depressive symptoms (BDI) respectively. Correlation analyses revealed significant associations between hippocampal volume and specific cognitive test scores. Left hippocampal volume demonstrated positive correlations with the CVLT recall total score (r = 0.0839) and the COWAT phonemic total score (r = 0.2974), while right hippocampal volume was positively associated with the RCFT delayed recall score (r = 0.1512). Both left and right hippocampal volumes exhibited weak negative correlations with PSQI total scores (r = −0.2035 and r = −0.1925, respectively), suggesting that poorer sleep quality may be linked to reduced hippocampal volume. Independent t-tests comparing sleep quality groups revealed a significant difference in K-MMSE total scores (t = 2.1892, p = 0.0358), indicating better cognitive performance in the good sleep quality group. Multivariate analysis of variance (MANOVA) by sex identified significant differences in hippocampal volumes and cognitive test scores, including left hippocampal volume (F = 10.435, p = 0.0028), right hippocampal volume (F = 10.173, p = 0.0031), SVLT recall total score (F = 16.921, p = 0.0002), and Stroop Test interference score (F = 4.7394, p = 0.0367).
Conclusions:
Conclusions: The alteration of hippocampal neural circuits and its relationship with general sleep quality was investigated by analyzing associations between hippocampal regional volumes, cognitive functions, and self-reported general sleep quality. These findings underscore the complex interplay among brain structure, cognitive function, and sleep quality. The results provide preliminary evidence suggesting that self-reported sleep latency may influence cognitive performance. Future research should incorporate objective sleep measures like polysomnography, in larger sample sizes, preferably with longitudinal designs to clarify causal relationships.
Higher Cognitive Functions:
Space, Time and Number Coding
Modeling and Analysis Methods:
Connectivity (eg. functional, effective, structural) 1
Diffusion MRI Modeling and Analysis
fMRI Connectivity and Network Modeling 2
Novel Imaging Acquisition Methods:
Diffusion MRI
Keywords:
Aging
Cognition
FUNCTIONAL MRI
Sleep
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Task-activation
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Patients
Was this research conducted in the United States?
No
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
NOTE: Any human subjects studies without IRB approval will be automatically rejected.
Yes
Were any animal research approved by the relevant IACUC or other animal research panel?
NOTE: Any animal studies without IACUC approval will be automatically rejected.
Not applicable
Please indicate which methods were used in your research:
Functional MRI
Diffusion MRI
Neuropsychological testing
Computational modeling
Which processing packages did you use for your study?
Free Surfer
Provide references using APA citation style.
Joo, E. Y., Kim, H., Suh, S., & Hong, S. B. (2014). Hippocampal Substructural Vulnerability to Sleep Disturbance and Cognitive Impairment in Patients with Chronic Primary Insomnia: Magnetic Resonance Imaging Morphometry. Sleep, 37(7), 1189–1198. https://doi.org/10.5665/sleep.3836
Kim, J. H., Ahn, J. H., Min, C. Y., Yoo, D. M., & Choi, H. G. (2021a). Association between sleep quality and subjective cognitive decline: Evidence from a community health survey. Sleep Medicine, 83, 123–131. https://doi.org/10.1016/j.sleep.2021.04.031
Künstler, E. C., Bublak, P., Finke, K., Koranyi, N., Meinhard, M., Schwab, M., & Rupprecht, S. (2023). The Relationship Between Cognitive Impairments and Sleep Quality Measures in Persistent Insomnia Disorder. Nature and Science of Sleep, 15, 491–498. https://doi.org/10.2147/NSS.S399644
Liu, C., Lee, S. H., Hernandez-Cardenache, R., Loewenstein, D., Kather, J., & Alperin, N. (2021). Poor sleep is associated with small hippocampal subfields in cognitively normal elderly individuals. Journal of Sleep Research, 30(5), e13362. https://doi.org/10.1111/jsr.13362
Noh, H. J., Joo, E. Y., Kim, S. T., Yoon, S. M., Koo, D. L., Kim, D., Lee, G.-H., & Hong, S. B. (2012). The relationship between hippocampal volume and cognition in patients with chronic primary insomnia. Journal of Clinical Neurology, 8(2), 130–138.
Sabeti, S., Al-Darsani, Z., Mander, B. A., Corrada, M. M., & Kawas, C. H. (2018). Sleep, hippocampal volume, and cognition in adults over 90 years old. Aging Clinical and Experimental Research, 30(11), 1307–1318. https://doi.org/10.1007/s40520-018-1030-x
Spanò, G., Weber, F. D., Pizzamiglio, G., McCormick, C., Miller, T. D., Rosenthal, C. R., Edgin, J. O., & Maguire, E. A. (2020). Sleeping with Hippocampal Damage. Current Biology, 30(3), 523-529.e3. https://doi.org/10.1016/j.cub.2019.11.072
Alperin, N., Wiltshire, J., Lee, S. H., Ramos, A. R., Hernandez-Cardenache, R., Rundek, T., Curiel Cid, R., & Loewenstein, D. (2019). Effect of sleep quality on amnestic mild cognitive impairment vulnerable brain regions in cognitively normal elderly individuals. Sleep, 42(3), zsy254.
De Looze, C., Feeney, J. C., Scarlett, S., Hirst, R., Knight, S. P., Carey, D., Meaney, J. F., & Kenny, R. A. (2022). Sleep duration, sleep problems, and perceived stress are associated with hippocampal subfield volumes in later life: Findings from The Irish Longitudinal Study on Ageing. Sleep, 45(1),
No