Altered Spontaneous Activity Induced by the State-dependent Personalized rTMS
Poster No:
72
Submission Type:
Abstract Submission
Authors:
Changyue Hou1, Meihua Yan1, Yuting Deng1, Sisi Jiang1, Hechun Li1, Jianfu Li1, Dezhong Yao1, Cheng Luo1
Institutions:
1University of Electronic Science and Technology of China, Chengdu, Sichuan
First Author:
Co-Author(s):
Introduction:
Emotion regulation (ER) is a vital sustainment for maintaining normal social interactions and individual psychological health. Using transcranial magnetic stimulation (TMS) to modulate emotional regulation is expected to be a powerful method for patients with neurological or psychiatric disorders. However, TMS efficacy shows significant differences between therapy protocols and individuals. An overlooked factor is the individual brain state during treatment. This study aimed to explore the influence of brain state on TMS effects.
Methods:
One hundred healthy participants were recruited and randomly divided into three groups. One group watched the neutral film (the neutral group) and received active TMS, and the other two groups watched the sadness film but received active and sham TMS respectively (the sad group and the sham group). Using resting-state functional magnetic resonance imaging, the amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) were investigated.
Results:
The sad group had different changes in neural activity (as measured by ALFF) in the right superior occipital gyrus and right middle frontal gyrus after TMS compared with the neutral group. Additionally, the change in the right superior occipital gyrus was correlated with the baseline FC between the right superior occipital gyrus and the target in the neutral group, whereas there was no similar association in the sad group. Notably, changes in neural activity in the right superior occipital gyrus and right middle frontal gyrus were related to changes in depression scale scores in the sad group.
Conclusions:
These findings may suggest that TMS during sad emotional film clips can induce state-dependent alterations in neural activity. Combining the emotional film, TMS, and fMRI, this study offers a unique perspective on state-dependent effects and may improve TMS treatment outcomes.This study was supported by the grant from Chengdu Science and Technology Bureau(2024-YF05-02056-SN).
Brain Stimulation:
TMS 1
Emotion, Motivation and Social Neuroscience:
Emotional Perception 2
Keywords:
Plasticity
Transcranial Magnetic Stimulation (TMS)
1|2Indicates the priority used for review
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Were any human subjects research approved by the relevant Institutional Review Board or ethics panel? NOTE: Any human subjects studies without IRB approval will be automatically rejected.
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Provide references using APA citation style.
Dinur-Klein, L., et al., Smoking cessation induced by deep repetitive transcranial magnetic stimulation of the prefrontal and insular cortices: a prospective, randomized controlled trial. Biological psychiatry, 2014. 76(9): p. 742-749.
Oathes, D., et al., Effects of Stimulation Site, Context, and Trauma History on Response to rTMS Treatment Among Patients With PTSD or Depression With Trauma. Biological Psychiatry, 2022. 91(9): p. S36.