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Brain mechanism of acupuncture of upper limb motor dysfunction after unilateral basal ganglia stroke

Poster No:

859

Submission Type:

Abstract Submission

Authors:

Tianjiao Xu¹, Jiliang Fang²

Institutions:

¹Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing, ²Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China

First Author:

Tianjiao Xu
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Beijing, Beijing

Co-Author:

Jiliang Fang
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Beijing, China

Introduction:

Acute stroke is the leading cause of death and disability among adults worldwide(Yu K, 2023), with nearly 80% of acute stroke patients experiencing upper limb motor dysfunction(Duncan PW, 1992). The recovery of upper limb function is crucial in the rehabilitation process of stroke survivors(Takebayashi T, 2022). However, the brain remodeling and compensatory mechanisms for the recovery of upper limb motor function after stroke are not yet clear, and there is currently no recognized treatment method.
REFERENCES:
1. Yu K, Chen XF, Guo J, Wang S, Huang XT, Guo Y, Dong SS, Yang TL. Assessment of bidirectional relationships between brain imaging derived phenotypes and stroke: a Mendelian randomization study BMC Med. 2023 Jul 25; 21 (1): 271
2. Duncan PW, Goldstein LB, Machar D, Divine GW, Feussner J. Measurement of motor recovery after stroke Output assessment and sample size requirements Stroke 1992 Aug; 23 (8): 1084-9
3. Takebayashi T, Takahashi K, Amano S, Gosho M, Sakai M, Hashimoto K, Hachisuka K, Uchiyama Y, Domen K. Robot Assisted Training as Self Training for Upper Limb Hemiplegia in Chronic Stroke: A Randomized Controlled Trial Stroke 2022 Jul; 53 (7): 2182-2191

Methods:

Participants included 43 individuals with post-stroke hemiplegia and 28 healthy individuals. The post-stroke hemiplegia patients were randomly assigned to either a true acupoint group (n=23) or a false acupoint group (n=20) for clinical scale evaluation and magnetic resonance imaging. The true acupoint group received acupuncture on specific acupoints on hands and feet, while the false acupoint group received acupuncture on non-specific points near the meridian. Regions of interest in the brain were selected, including the bilateral primary motor cortex (M1), dorsolateral anterior motor cortex (PMD), ventrolateral anterior motor cortex (PMV), and supplementary motor area (SMA). Compare the Granger causality (GC) changes between the true and false acupoint group, and baseline GC changes between the experimental group and the control group.

Results:

(1) Clinical Scale Scoring: following acupuncture treatment, the true acupoint group showed a significant improvement in motor function, along with a decrease in neurological deficit. However, in the false acupoint group, there was a slight decrease in upper limb movement scores on the NIHSS scale. (2) Imaging results :①Compared to baseline,the connectivities of the false acupoint group between SMA.R→M1.R, PMD.R→M1.R, SMA.R→SMA.L, SMA.L→SMA.R, M1.L→PMV.R was stronger.②Compared to baseline,the connectivities of the true acupoint group between PMV.R→SMA.R, PMD.R→M1.R, SMA.L→PMD.R was stronger.③Compared to control group, the connectivitied of the experimental group between PMV.R→SMA.R was stronger,and the connectivities between SMA.R→M1.L, M1.L→SMA.R, M1.R→PMD.L was weaker.

Conclusions:

Acupuncture can aid in the recovery of hand motor skills and improve brain function. Acupuncture at specific acupoints enhances positive connectivities in the brain.

Higher Cognitive Functions:

Executive Function, Cognitive Control and Decision Making

Learning and Memory:

Neural Plasticity and Recovery of Function ¹

Modeling and Analysis Methods:

fMRI Connectivity and Network Modeling ²

Motor Behavior:

Motor Planning and Execution

Physiology, Metabolism and Neurotransmission:

Neurophysiology of Imaging Signals

Keywords:

Basal Ganglia

fMRI CONTRAST MECHANISMS

FUNCTIONAL MRI

Movement Disorder

Treatment

^1|2Indicates the priority used for review

Abstract Information

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Healthy subjects only or patients (note that patient studies may also involve healthy subjects):

Patients

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Functional MRI

Behavior

For human MRI, what field strength scanner do you use?

3.0T

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Provide references using APA citation style.

1. Yu K, Chen XF, Guo J, Wang S, Huang XT, Guo Y, Dong SS, Yang TL. Assessment of bidirectional relationships between brain imaging derived phenotypes and stroke: a Mendelian randomization study BMC Med. 2023 Jul 25; 21 (1): 271
2. Duncan PW, Goldstein LB, Machar D, Divine GW, Feussner J. Measurement of motor recovery after stroke Output assessment and sample size requirements Stroke 1992 Aug; 23 (8): 1084-9
3. Takebayashi T, Takahashi K, Amano S, Gosho M, Sakai M, Hashimoto K, Hachisuka K, Uchiyama Y, Domen K. Robot Assisted Training as Self Training for Upper Limb Hemiplegia in Chronic Stroke: A Randomized Controlled Trial Stroke 2022 Jul; 53 (7): 2182-2191

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