Poster No:
851
Submission Type:
Abstract Submission
Authors:
James Antony1, Zachariah Reagh2, Charan Ranganath3
Institutions:
1Cal Poly, SLO, San Luis Obispo, CA, 2Washington University in St. Louis, St. Louis, MO, 3UC Davis, Davis, CA
First Author:
Co-Author(s):
Introduction:
Although experience unfolds linearly over time, we often need to link events across temporal gaps to support the acquisition of organized knowledge. This requires loading and offloading neural states in support of understanding and achieving current goals. Additionally, sometimes the boundaries between events are defined by spatial or other clearly demarcated boundaries (e.g., walking through a doorway), whereas other times they are more subtle (e.g., change in a conversation topic). Here, we ran a naturalistic fMRI experiment to ask how the brain switches and stitches together causally connected events separated across time and with different types of boundaries.
Methods:
Participants watched and recalled a TV show featuring five temporally interleaved storylines with clear causal structure. Notably, some transitions across storylines featured spatiotemporal changes (ST), while others were storyline only (SO) (i.e., the conversation topic changed within-scene), but both types of transitions involved changing to previously established storylines.
Results:
Behaviorally, causal structure significantly influenced recall organization. Neurally, univariate boundary responses substantially differed between ST and SO boundaries across the brain. Additionally, using greedy state boundary search, a (visual) control region showed neural event boundaries only at spatiotemporal transitions, whereas the angular gyrus had boundaries in both cases. Moreover, pattern similarity analyses revealed that angular gyrus patterns were more similar for scenes within versus across storylines (while controlling for time), suggesting it may enable mental bridging across temporal gaps.
Conclusions:
In sum, these findings highlight the importance of accounting for causal structure – and their underlying neural substrates – in scaffolding knowledge building and organizing recall.
Learning and Memory:
Long-Term Memory (Episodic and Semantic) 1
Modeling and Analysis Methods:
Activation (eg. BOLD task-fMRI)
fMRI Connectivity and Network Modeling
Multivariate Approaches 2
Novel Imaging Acquisition Methods:
BOLD fMRI
Keywords:
Cognition
Cortex
FUNCTIONAL MRI
Learning
Memory
Multivariate
Open Data
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Task-activation
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Healthy subjects
Was this research conducted in the United States?
Yes
Are you Internal Review Board (IRB) certified?
Please note: Failure to have IRB, if applicable will lead to automatic rejection of abstract.
Yes, I have IRB or AUCC approval
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
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Yes
Were any animal research approved by the relevant IACUC or other animal research panel?
NOTE: Any animal studies without IACUC approval will be automatically rejected.
No
Please indicate which methods were used in your research:
Functional MRI
Structural MRI
Behavior
For human MRI, what field strength scanner do you use?
3.0T
Which processing packages did you use for your study?
FSL
Other, Please list
-
fMRIPREP, nilearn, scikitlearn
Provide references using APA citation style.
not applicable
No