Poster No:
1732
Submission Type:
Abstract Submission
Authors:
Leila Nategh1, Natalia Egorova-Brumley2
Institutions:
1Florey Institute of Neuroscience and Mental Health, Austin, Heidelberg, Victoria, Australia, 2Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia
First Author:
Leila Nategh
Florey Institute of Neuroscience and Mental Health, Austin, Heidelberg
Victoria, Australia
Co-Author:
Natalia Egorova-Brumley
Melbourne School of Psychological Sciences, University of Melbourne
Melbourne, Victoria, Australia
Introduction:
Osteoarthritis (OA), a prevalent inflammatory joint disorder among aging populations, is increasingly recognized to involve central nervous system (CNS) alterations mediated by systemic inflammation. Neuroimaging markers, including choroid plexus (CP) and ventricular volumes, indicative of neuroinflammation and glymphatic dysfunction, remain unexplored in OA.
Methods:
In this cross-sectional, case-control neuroimaging study, we examined 62 adults comprising 31 hip OA patients and 31 healthy controls (mean age controls: 69; OA: 63 years). MRI-derived volumes of bilateral CP and lateral, third, and fourth ventricles were analysed. OA patients underwent clinical assessments, including Numeric Rating Scale (NRS) for pain, Western Ontario and McMaster Universities Arthritis Index (WOMAC), and Pittsburgh Sleep Quality Index (PSQI).
In this cross-sectional neuroimaging study, we examined 31 adults with hip OA (mean age: 63 ± 6.9 years). MRI-derived volumes of bilateral CP and lateral, third, and fourth ventricles were analysed. Participants underwent clinical assessments, including the Numeric Rating Scale (NRS) for pain, the Western Ontario and McMaster Universities Arthritis Index (WOMAC), and the Pittsburgh Sleep Quality Index (PSQI).
Results:
Significant positive correlations were observed between left CP volume and pain severity (NRS; ρ = 0.370, p = 0.040), and between total ventricular volume and NRS pain scores (ρ = 0.380, p = 0.034). Additionally, both total and lateral ventricular volumes correlated significantly with stiffness scores from WOMAC-B (ρ = 0.359, p = 0.048; ρ = 0.400, p = 0.029, respectively). No significant associations were found between PSQI scores and either CP or ventricular volumes.
Conclusions:
These findings suggest that neuroimaging biomarkers reflect direct neuroimmune and glymphatic processes associated with chronic inflammation in OA, independently of sleep disturbances. Our results emphasize the potential utility of these biomarkers for elucidating the CNS mechanisms underlying pain and stiffness in osteoarthritis.
Neuroanatomy, Physiology, Metabolism and Neurotransmission:
Cortical Anatomy and Brain Mapping 1
Novel Imaging Acquisition Methods:
Anatomical MRI
Perception, Attention and Motor Behavior:
Perception: Pain and Visceral 2
Keywords:
MRI
Pain
Other - Osteoarthritis, Chronic Pain, Cortical Thinning, Neurobiological Mechanisms of Pain
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
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Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Patients
Was this research conducted in the United States?
No
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
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Were any animal research approved by the relevant IACUC or other animal research panel?
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Please indicate which methods were used in your research:
Structural MRI
For human MRI, what field strength scanner do you use?
1T
Which processing packages did you use for your study?
Free Surfer
Provide references using APA citation style.
1. Fleischer, V., et al. (2021). Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans. Proceedings of the National Academy of Sciences, 118(36), e2025000118. https://doi.org/10.1073/pnas.2025000118
2. Crook, J. E., et al. (2020). Linear vs volume measures of ventricle size: Relation to present and future gait and cognition. Neurology, 94(6), e549. https://doi.org/10.1212/WNL.0000000000008840Mayo Clinic
No