Poster No:
218
Submission Type:
Abstract Submission
Authors:
Bing Yao1, John DeLuca1, Glenn Wylie1
Institutions:
1Kessler Foundation, West Orange, NJ
First Author:
Co-Author(s):
Introduction:
Cognitive fatigue (CF) is one of the most prevalent and persistent symptoms in Multiple Sclerosis (MS). Previously, we have developed a fatigue induction paradigm to study brain activation and behavior as CF develops in MS and have consistently shown the caudate nucleus (CN) of the basal ganglia as well as in the ventro-medial prefrontal cortex (vmPFC) to be related to CF. Separately, structural imaging has shown that MS is associated with increased iron deposition in the CN. Here, we tested the hypothesis that the concentration of iron in the CN is related to CF-related brain activation, and that the location of this activation would be in the CN and vmPFC.
Methods:
Seventy individuals with MS and 30 matched controls (matched on age, education and sex) participated. The concentration of iron in the CN was assessed by acquiring 3D multi-echo gradient-echo images (MEGRE) on a 3T Siemens scanner. Quantitative R2* maps were derived from using an algorithm we developed previously [Yao, et al, Neuroimage, 2008].
All participants worked through seven blocks of a task-switching paradigm while fMRI data were acquired. Each block consisted of 32 stimuli and took approximately 4 min to complete. Participants rated their level of CF at baseline and after each task block.
Results:
The CF-induction paradigm induced more CF in individuals with MS than in controls, as shown by a Group x Block interaction (F(7, 706)=3.80, p<0.001,η2p=0.04) in which CF increased over successive blocks for the MS group more than for the control group. In the neuroimaging data, there was a Group x CF x Iron concentration interaction in the vmPFC and CN.
Conclusions:
We are the first to demonstrate a link between iron deposition in the CN and CF-related brain activation in MS. Iron deposition may therefore represent an attractive target for interventions designed to reduce CF in MS.
Disorders of the Nervous System:
Neurodegenerative/ Late Life (eg. Parkinson’s, Alzheimer’s) 1
Emotion, Motivation and Social Neuroscience:
Emotion and Motivation Other 2
Keywords:
Basal Ganglia
Other - Multiple Sclerosis, Iron deposition, Fatigue
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Task-activation
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Patients
Was this research conducted in the United States?
Yes
Are you Internal Review Board (IRB) certified?
Please note: Failure to have IRB, if applicable will lead to automatic rejection of abstract.
Yes, I have IRB or AUCC approval
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
NOTE: Any human subjects studies without IRB approval will be automatically rejected.
Yes
Were any animal research approved by the relevant IACUC or other animal research panel?
NOTE: Any animal studies without IACUC approval will be automatically rejected.
Not applicable
Please indicate which methods were used in your research:
Functional MRI
Structural MRI
Neuropsychological testing
For human MRI, what field strength scanner do you use?
3.0T
Which processing packages did you use for your study?
AFNI
FSL
Provide references using APA citation style.
Yao B, Li TQ, Gelderen P van, Shmueli K, de Zwart JA, Duyn JH (2009) Susceptibility contrast in high field MRI of human brain as a function of tissue iron content. Neuroimage 44:1259–1266.
No