Poster No:
1464
Submission Type:
Abstract Submission
Authors:
Wai Ho Savio Wong1, Anais Chia2, Hey-Tou Chiu1, Hannah Sou1
Institutions:
1The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2University College London, London, United Kingdom
First Author:
Co-Author(s):
Anais Chia
University College London
London, United Kingdom
Hey-Tou Chiu
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Hannah Sou
The Chinese University of Hong Kong
Hong Kong, Hong Kong
Introduction:
Recent advancements in naturalistic neuroscience have highlighted the advantages of employing naturalistic viewing paradigms in identifying functional connectivity and its association with individual differences. While various studies have utilized diverse movie clips for the naturalistic viewing condition, some researchers have proposed that social videos and well-known Hollywood movies may enhance the predictability of functional connectivity (Finn and Bandettini, 2021). However, these movie clips frequently incorporate narratives and are designed to be viewed with audio, which may bias connectivity analyses in language and auditory regions. Conversely, muting the audio may hinder the interpretation of the content of the clips. In this study, we utilized a five-minute dialogue-free cartoon animation featuring engaging content as the naturalistic paradigm. We intend to compare this approach with the conventional fixation resting-state condition.
Methods:
Eighteen healthy individuals participated in two resting-state fMRI scans: one with standard fixation and another viewing a dialogue-free animation, "Presto" (2008). Data were acquired using a Siemens MAGNETOM Prisma 3T MR scanner. Functional scans used an echoplanar pulse sequence (TR/TE = 1240/30 ms; FA = 63°; FOV = 208x208 mm; matrix size = 84x84; 54 axial slices; voxel size = 2.5 mm isotropic) with SMS factor of 3, collecting 242 volumes. Anatomical reference images were obtained using MPRAGE (TR/TE = 1900/2.15 ms; FA = 9°; FOV = 256x256 mm; 176 axial slices; voxel size = 1 mm isotropic).
Results:
The naturalistic viewing condition produced enhanced functional connectivity within the default mode network compared to fixation. Seed-based analysis using the medial prefrontal cortex revealed stronger functional connectivity with the frontal pole and insular cortex during animation viewing versus fixation.
Conclusions:
Our findings demonstrated that a dialogue-free animation can be utilized, comparable to conventional fixation, for identifying functional connectivity within DMN. The connectivity between the medial frontal cortex and the frontal pole aligns with previous studies suggesting the role of this region in humor processing (Jääskeläinen et al., 2016). The utilization of a non-narrative animation offers several advantages for studying functional connectivity. Its accessibility across age groups and cultures, due to the absence of language requirements, renders it suitable for diverse populations. Presenting the complete, self-contained animation minimizes variability arising from prior exposure or memory effects associated with excerpts from longer films. Future research could explore the predictive power of various naturalistic stimuli, including humorous or socially relevant animations, for assessing individual differences in cognitive and affective traits.
Modeling and Analysis Methods:
Connectivity (eg. functional, effective, structural) 2
fMRI Connectivity and Network Modeling 1
Keywords:
Experimental Design
FUNCTIONAL MRI
NORMAL HUMAN
1|2Indicates the priority used for review
By submitting your proposal, you grant permission for the Organization for Human Brain Mapping (OHBM) to distribute your work in any format, including video, audio print and electronic text through OHBM OnDemand, social media channels, the OHBM website, or other electronic publications and media.
I accept
The Open Science Special Interest Group (OSSIG) is introducing a reproducibility challenge for OHBM 2025. This new initiative aims to enhance the reproducibility of scientific results and foster collaborations between labs. Teams will consist of a “source” party and a “reproducing” party, and will be evaluated on the success of their replication, the openness of the source work, and additional deliverables. Click here for more information.
Propose your OHBM abstract(s) as source work for future OHBM meetings by selecting one of the following options:
I do not want to participate in the reproducibility challenge.
Please indicate below if your study was a "resting state" or "task-activation” study.
Resting state
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Healthy subjects
Was this research conducted in the United States?
No
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
NOTE: Any human subjects studies without IRB approval will be automatically rejected.
Yes
Were any animal research approved by the relevant IACUC or other animal research panel?
NOTE: Any animal studies without IACUC approval will be automatically rejected.
Not applicable
Please indicate which methods were used in your research:
Functional MRI
For human MRI, what field strength scanner do you use?
3.0T
Which processing packages did you use for your study?
SPM
Provide references using APA citation style.
Finn, E. S., & Bandettini, P. A. (2021). Movie-watching outperforms rest for functional connectivity-based prediction of behavior. NeuroImage, 235, 117963.
Jääskeläinen, I. P., Pajula, J., Tohka, J., Lee, H. J., Kuo, W. J., & Lin, F. H. (2016). Brain hemodynamic activity during viewing and re-viewing of comedy movies explained by experienced humor. Scientific reports, 6(1), 27741.
No