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Alterations in brain functional networks of recent suicide attempts in depression patients

Poster No:

557

Submission Type:

Abstract Submission

Authors:

Na Shen¹, Chen Zhilu², Yiwen Wang³, Shui Tian⁴, Yingying Hang⁵, Zhijian Yao⁶

Institutions:

¹Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, ²Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medica Nanjing Medical University, Nanjing, Jiangsu, ³Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University,, Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanji, Jiangsu, ⁴Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ⁵Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanji, Jiangsu, ⁶Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu

First Author:

Na Shen
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University
Nanjing, Jiangsu

Co-Author(s):

Chen Zhilu
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medica Nanjing Medical University
Nanjing, Jiangsu

Yiwen Wang
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University,
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanji, Jiangsu

Shui Tian
Department of Radiology, the First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu

Yingying Hang
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanji, Jiangsu

Zhijian Yao
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu

Introduction:

To examine alterations in brain network functional connectivity (FC), intrinsic topological properties, and their associations with different dimensions of impulsivity in patients with major depressive disorder (MDD) who have recently attempted suicide (RSA).

Methods:

From June 2012 to May 2024, inpatients diagnosed with MDD were recruited and categorized into two groups based on the presence or absence of a history of suicide attempts: the non-suicide attempt (NSA) group (n = 327) and the RSA group (n = 133). Additionally, 301 age- and sex-matched healthy controls were included. All participants underwent resting-state functional MRI (rs-fMRI) scans and clinical assessments. Whole-brain functional networks were constructed to identify differences in FC across three groups. Subsequently, variations in topological properties between patient groups were analyzed, and partial correlation analyses were conducted to explore the relationships between FC, topological properties, and impulsivity dimensions within the RSA group.

Results:

The RSA group exhibited significantly reduced network FC compared to the NSA group (p < 0.05, FWE-corrected), involving 30 nodes and 46 edges. The affected regions were primarily located in the superior frontal gyrus, middle insula, dorsal prefrontal cortex, ventral prefrontal cortex, parietal lobe, precentral gyrus, temporal lobe, and inferior parietal lobule. Analysis of topological properties revealed decreased nodal efficiency and degree centrality in the left middle insula within the RSA group (p < 0.05, FDR-corrected), which were negatively correlated with elevated cognitive impulsivity.

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·The affected regions were primarily located in the superior frontal gyrus, middle insula, dorsal prefrontal cortex, ventral prefrontal cortex, parietal lobe, precentral gyrus, temporal lobe, and infer

·Analysis of topological properties revealed decreased nodal efficiency and degree centrality in the left middle insula within the RSA group

Conclusions:

MDD patients with RSA demonstrate diminished network FC, disrupted topological properties, and impaired capacity for optimal information processing. The reduction in information transmission efficiency within the insula is associated with heightened cognitive impulsivity in RSA patients.

Disorders of the Nervous System:

Psychiatric (eg. Depression, Anxiety, Schizophrenia) ¹

Modeling and Analysis Methods:

fMRI Connectivity and Network Modeling ²

Keywords:

FUNCTIONAL MRI

Other - Major depressive disorder; Recent suicide attempt; Impulsivity

^1|2Indicates the priority used for review

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Healthy subjects only or patients (note that patient studies may also involve healthy subjects):

Patients

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Were any human subjects research approved by the relevant Institutional Review Board or ethics panel? NOTE: Any human subjects studies without IRB approval will be automatically rejected.

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Please indicate which methods were used in your research:

Functional MRI

Neuropsychological testing

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3.0T

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