Poster No:
77
Submission Type:
Abstract Submission
Authors:
Maheen Adamson1, Windy McNerney2, Shan Siddiqi3, John Coetzee4, Girish Swaminath2, Lien-Lien Wu2, Beatriz Hernandez2, Laura Lazzeroni2, Elika Eshghi2, Jerome Yesavage4
Institutions:
1Women’s Operational Military Exposure Network Center of Excellence, Palo Alto, CA, 2VA Palo Alto Health Care System, Palo Alto, CA, 3Harvard Medical School, Boston, MA, 4Stanford, Palo Alto, CA
First Author:
Maheen Adamson, PhD
Women’s Operational Military Exposure Network Center of Excellence
Palo Alto, CA
Co-Author(s):
Introduction:
Brain derived neurotrophic factor (BDNF) is the best-known predictor of patient response to repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression. BDNF is a protein encoded by the BDNF gene that plays a significant role in the growth and maintenance of neurons. RTMS is also used as a treatment for traumatic brain injury (TBI), but biological markers underlying treatment response for TBI have not been clearly identified. Here we examine the relationship between levels of BDNF and default mode network (DMN) connectivity in a double-blind randomized clinical trial using rTMS for Veterans with TBI.
Methods:
Twenty-four Veterans (21 male; mean age: 44 yrs.) with TBI were enrolled in treatment (n = 11) or sham (n = 10) at VA Palo Alto. FDA approved parameters for depression were used (10 Hz stimulation at left dorsolateral prefrontal cortex). Blood samples and MRI scans were collected at baseline and post treatment (T20).
Results:
Treatment did not significantly affect BDNF levels (Active: -0.31±3.02; Sham: 0.25±3.10) or DMN connectivity (Active: -0.35±2.15; Sham: -1.64±1.46; p>0.1). BDNF change was significantly correlated with DMN connectivity (p< .0211). At T20 DMN was the outcome, there were no significant effects of treatment on BDNF levels, baseline DMN or treatment/sham (p> 0.1). There was an overall effect of age on post T20 DMN (p=.0496).
Conclusions:
Results show a correlation between BDNF change and DMN connectivity with higher BDNF levels associated with lower DMN connectivity – this relationship being an indicator of improved brain function. This association is not driven by rTMS treatment. Although the sample size is small, biomarker targets for rTMS treatment in TBI are important to study as these patients suffer from numerous psychiatric problems.
Brain Stimulation:
TMS 1
Disorders of the Nervous System:
Neurodegenerative/ Late Life (eg. Parkinson’s, Alzheimer’s)
Physiology, Metabolism and Neurotransmission:
Physiology, Metabolism and Neurotransmission Other 2
Keywords:
ADULTS
Blood
MRI
Psychiatric Disorders
Transcranial Magnetic Stimulation (TMS)
Trauma
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Other
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Patients
Was this research conducted in the United States?
Yes
Are you Internal Review Board (IRB) certified?
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Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
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Yes
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Not applicable
Please indicate which methods were used in your research:
Functional MRI
Other, Please specify
-
bloodwork
For human MRI, what field strength scanner do you use?
3.0T
Which processing packages did you use for your study?
Free Surfer
Provide references using APA citation style.
Luo, J., Zheng, H., Zhang, L., Zhang, Q., Li, L., Pei, Z., & Hu, X. (2017). High-frequency repetitive transcranial magnetic stimulation (rTMS) improves functional recovery by enhancing neurogenesis and activating BDNF/TrkB signaling in ischemic rats. International Journal of Molecular Sciences, 18(2), 455.
Qian, F. F., He, Y. H., Du, X. H., Lu, H. X., He, R. H., & Fan, J. Z. (2022). Repetitive transcranial magnetic stimulation promotes neurological functional recovery in rats with traumatic brain injury by upregulating synaptic plasticity-related proteins. Neural regeneration research.
Cheeran, B., Talelli, P., Mori, F., Koch, G., Suppa, A., Edwards, M., ... & Rothwell, J. C. (2008). A common polymorphism in the brain‐derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS. The Journal of physiology, 586(23), 5717-5725.
No