Poster No:
2058
Submission Type:
Abstract Submission
Authors:
Xiaoyun Li1, Richu Jin2, Xinxin Lin1, Weiwei Peng3
Institutions:
1Shenzhen University, Shenzhen, Guangdong, 2Shenzhen Polytechnic University, Shenzhen, Guangdong, 3Shenzhen University, Shenzhen, --- Select One ---
First Author:
Xiaoyun Li
Shenzhen University
Shenzhen, Guangdong
Co-Author(s):
Richu Jin
Shenzhen Polytechnic University
Shenzhen, Guangdong
Xinxin Lin
Shenzhen University
Shenzhen, Guangdong
Weiwei Peng
Shenzhen University
Shenzhen, --- Select One ---
Introduction:
Subjective pain perception involves complex interactions between bottom-up nociceptive inputs and top-down cognitive processes, with subjective pain perception greatly shaped by expectations (Wiech, 2016; Wiech, Ploner, & Tracey, 2008). Studies have shown that the dorsolateral prefrontal cortex (DLPFC) plays a key role in the suppression of pain and the maintenance of pain inhibition, as well as the modulation of pain anticipation (Atlas & Wager, 2012; Lorenz, Minoshima, & Casey, 2003; Seminowicz & Moayedi, 2017; Wager et al., 2004). High frequency (≥ 5 Hz) repetitive transcranial magnetic stimulation (rTMS) have the potential to elevate cortical excitability, thereby reducing certain chronic pain conditions (Lefaucheur, 2016; Lefaucheur et al., 2020; Lefaucheur et al., 2008). Hence, it suggests that high-frequency rTMS targeting the DLPFC may alleviate pain perception by regulating the process of pain anticipation.
Methods:
Using a double-blinded, sham-controlled, within-subject design, 36 healthy participants were recruited to undergo two sessions of active or sham 10Hz-rTMS over the left DLPFC, separated by 7 days. Subjective pain perception induced by noxious laser stimuli were assessed using a pain-rating task, during which cues indicating the intensity (no-pain and pain) and certainty (certain or uncertain) of the forthcoming laser stimulation were used to manipulate pain anticipation. For each participant, behavioral and neural responses were assessed before and after rTMS application. We compared the effects of rTMS on pain anticipation and perception. In cases where rTMS influenced measurements related to both pain anticipation and perception, Pearson correlation analysis was further conducted to assess the relationship between anticipatory and pain-evoked responses.
Results:
For behavioral responses, compared to sham stimulation, DLPFC-rTMS significantly reduced pain intensity ratings during the pain anticipation stage, as well as the subjective pain intensity and unpleasantness ratings during the pain perception stage. In terms of neural responses, compared to sham stimulation, DLPFC-rTMS decreased the amplitude of the contingent negative variation (CNV) over the target region, which evoked by the anticipatory cue stimuli, and reduced the high-frequency gamma oscillation power evoked by painful stimuli. Mediation analysis further revealed that DLPFC-rTMS suppresses pain-evoked gamma neural oscillations by regulating CNV activity during the anticipation phase.
Conclusions:
By modulating cognitive processes related to pain anticipation, DLPFC-rTMS not only helps to alleviate subjective pain perception but also provides new therapeutic approaches for pain prevention and intervention.
Brain Stimulation:
TMS 2
Perception, Attention and Motor Behavior:
Perception: Pain and Visceral 1
Keywords:
Electroencephaolography (EEG)
Pain
1|2Indicates the priority used for review
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Please indicate below if your study was a "resting state" or "task-activation” study.
Task-activation
Healthy subjects only or patients (note that patient studies may also involve healthy subjects):
Healthy subjects
Was this research conducted in the United States?
No
Were any human subjects research approved by the relevant Institutional Review Board or ethics panel?
NOTE: Any human subjects studies without IRB approval will be automatically rejected.
Yes
Were any animal research approved by the relevant IACUC or other animal research panel?
NOTE: Any animal studies without IACUC approval will be automatically rejected.
Not applicable
Please indicate which methods were used in your research:
EEG/ERP
TMS
Provide references using APA citation style.
1. Atlas, L. Y., & Wager, T. D. (2012). How expectations shape pain. Neurosci Lett, 520(2), 140-148.
2. Lefaucheur, J. P. (2016). Cortical neurostimulation for neuropathic pain: state of the art and perspectives. Pain, 157 Suppl 1, S81-s89.
3. Lefaucheur, J. P., Aleman, A., Baeken, C., Benninger, D. H., Brunelin, J., Di Lazzaro, V., . . . Ziemann, U. (2020). Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014-2018). Clin Neurophysiol, 131(2), 474-528.
4. Lefaucheur, J. P., Antal, A., Ahdab, R., Ciampi de Andrade, D., Fregni, F., Khedr, E. M., . . . Paulus, W. (2008). The use of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) to relieve pain. Brain Stimul, 1(4), 337-344.
5. Lorenz, J., Minoshima, S., & Casey, K. L. (2003). Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain, 126(Pt 5), 1079-1091.
6. Seminowicz, D. A., & Moayedi, M. (2017). The Dorsolateral Prefrontal Cortex in Acute and Chronic Pain. J Pain, 18(9), 1027-1035.
7. Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., . . . Cohen, J. D. (2004). Placebo-induced changes in FMRI in the anticipation and experience of pain. Science, 303(5661), 1162-1167.
8. Wiech, K. (2016). Deconstructing the sensation of pain: The influence of cognitive processes on pain perception. Science, 354(6312), 584-587.
9. Wiech, K., Ploner, M., & Tracey, I. (2008). Neurocognitive aspects of pain perception. Trends Cogn Sci, 12(8), 306-313.
No