BrainCAP: an open-source neuroimaging toolkit to analyze brain co-activation patterns

Brisbane Convention & Exhibition Centre 

The analysis of moment-to-moment changes in co-activation patterns (CAPs) in functional MRI (fMRI) has been useful for studying dynamic properties of neural activity. This method is based on clustering fMRI time-frames into several recurrent spatial patterns within and across subjects [1]. Studies have also focused on quantifying properties of the temporal organization of CAPs, such as fractional occupancy [2]. The analyses of co-activations are computationally intensive, requiring the clustering of high-dimensional data concatenated over subjects. Further, while a variety of analytic choices are involved in studying CAPs, the field lacks a unified open-source platform to allow a robust feature selection required for reproducible mappings of brain and behavioral measurements.