Integrating intracranial stimulation with brain connectivity in language impairment and recovery

Brisbane Convention & Exhibition Centre 

Neurological conditions such as stroke and glioma are major causes of disability worldwide, accounting for millions of deaths per year and long-lasting cognitive impairments¹. Recent studies show that brain network disruption can predict survival rates in glioma and model cognitive impairment in stroke^2,3. However, a similar connectivity framework to model cognitive functioning after surgery is currently lacking.

Here, we introduce a novel method that integrates direct electrical brain stimulation (DES) with MRI-driven functional network mapping to recover the white matter substrates causally implicated in language production.