Genetically informed brain morphometric similarities revealing suicide risk in bipolar disorder

Brisbane Convention & Exhibition Centre 

Suicide in bipolar disorder (BD) with high heritability (Turecki, G., 2019; Erlangsen, A., 2020) is characterized as a dysconnectivity syndrome (Wang H., 2022; Wang, H., 2020) 3-4. While traditionally focused on single-level biological data, suicide-related imaging-genetic studies are now shifting towards a multidimensional approach to spatial correspondence (Li, J., 2024; Qin, K., 2024). It poses challenges for the exploration of multifaceted reliable genetic landscape responsible for reproducible neuroanatomical alterations by suicidal effects. Beyond the exploration of macro-micro-coupling, more tangible and compelling proof-of-principle with paired measures of multi-biological characteristics is also urgently needed to develop personalized risk assessments in clinic (Wang, J., 2024).