Energetic Profiles and Distribution of Neurons and Glia in the Human Brain

Brisbane Convention & Exhibition Centre 

Glucose is the primary fuel of the human brain, and its metabolism is tightly regulated on a cellular level. Neurons and glial cells, including astrocytes (Ast), microglia (Mic), and oligodendrocytes (Oli), distribute heterogeneously across the brain and possess divergent metabolic profiles [1]. These metabolic profiles have not been studied in the human brain. Metabolic differences within the cell types emerge from differential gene expressions. We leveraged transcriptomic data of post-mortem brains from the Allen Human Brain Atlas (AHBA) to characterize the metabolic profiles of brain cells and investigate their expression patterns across the human cortex and subcortex [2].