Structural Bias on the Assessment of Periventricular Flow as Revealed by Post-mortem Human Brain

Brisbane Convention & Exhibition Centre 

Diffusion tensor image analysis along the perivascular space (DTI-ALPS) has emerged to evaluate glymphatic function in Alzheimer's disease (Taoka, 2020). However, the underlying mechanism for ALPS change remains controversial(Wright et al., 2023; Taoka et al., 2024). With the post-mortem brains DTI with autopsy-confirmed AD change, we aim to explore and correct the structural bias on the ALPS index.