Chronotype Subtypes Explain Unique Behavioral Profiles and Health Associations

Brisbane Convention & Exhibition Centre 

Chronotype is a multifaceted construct linked to a broad spectrum of behaviors and health outcomes (Hasler, 2023; Montaruli et al., 2021). Individuals with similar chronotypes may exhibit distinct brain and behavioral patterns. To investigate this relationship, we developed a holistic pattern-learning algorithm. Our approach integrates three brain imaging modalities-regional gray matter volume, white matter microstructure, and functional connectivity-with 977 phenotypes, 1,447 diagnoses, and 133 medications from 27,030 UK Biobank participants. By disentangling chronotype subtypes, we move beyond simple dichotomies to uncover individual differences in chronotype expression and distinct brain-behavior patterns with potential health implications.