Comprehensive profiling of anaesthetised brain dynamics across phylogeny

Brisbane Convention & Exhibition Centre 

Anaesthetics act on molecular signalling to suppress behaviour. Combined with neuroimaging, they provide a unique opportunity to investigate how local neural dynamics mediate the link between microscale chemoarchitecture and the organism's functional repertoire. However, most studies focus on single species, single anaesthetics, and hand-picked properties of neural activity (e.g. entropy, power spectrum), providing a fundamentally incomplete picture.

To overcome these challenges, we systematically characterise how diverse anaesthetics perturb the entire dynamical profile of the invertebrate, murine and primate brain cross thousands of time-series features (Fig.1).