Mental Health in the UK Biobank: An Updated Roadmap for Brain-behavior Associations

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The UK Biobank (UKB) is an essential resource for research in neuroimaging and population mental health (Dutt et al., 2021). However, the dataset has become increasingly complex to navigate due to the ongoing collection and release of follow-up data. In this study, we aimed to establish an up-to-date roadmap for neuroimaging research in mental health using the UKB dataset, with a focus on updating the univariate effect sizes for associations between imaging-derived phenotypes (IDPs) and all available mental health phenotypes (MHPs). To set the stage for future longitudinal studies, we also calculated effect sizes for repeated measures correlations between IDPs and MHPs assessed at two timepoints (Bakdash & Marusich, 2017).